Effects of valproate on brain volumes in pediatric bipolar disorder: A preliminary study
| Autor: | Benson Mwangi, Ives Cavalcante Passos, Robert Suchting, Jair C. Soares, Cristian Patrick Zeni, Isabelle E. Bauer, Mon-Ju Wu, Giovanna Zunta-Soares, Fadwa Cazala, Danielle Spiker |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Oncology medicine.medical_specialty Bipolar Disorder Adolescent Neuroscience (miscellaneous) Amygdala Neuroprotection 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Medicine Radiology Nuclear Medicine and imaging Bipolar disorder Child business.industry Valproic Acid Brain Bayes Theorem medicine.disease Magnetic Resonance Imaging Treatment period 030227 psychiatry Pediatric bipolar disorder Psychiatry and Mental health Brain region medicine.anatomical_structure Female lipids (amino acids peptides and proteins) business 030217 neurology & neurosurgery |
| Zdroj: | Psychiatry Research: Neuroimaging. 278:65-68 |
| ISSN: | 0925-4927 |
| DOI: | 10.1016/j.pscychresns.2018.05.006 |
| Popis: | Sodium valproate (VPA) has well-established neuroprotective effects and is recommended as treatment in bipolar disorder patients. The neural effects of VPA in pediatric bipolar disorder (PBD) have yet to be established. This preliminary study explored the effects of VPA on brain structure in PBD. Fourteen PBD patients (10 males; mean = 13.43 ± 3.05 years old) underwent a structural MRI before and after a 6-week VPA treatment period. Bayesian linear mixed modeling explored seven brain region volumes as a function of dichotomous pre/post time. Results showed a decrease in amygdala volume over time. These findings need to be confirmed by large-scale, longitudinal studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect