Subchronic oral toxicity of turmeric oleoresin in pigs
| Autor: | J.C. Larsen, G. Würtzen, N. Bille, E.V. Hansen |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Male
Swine Urinary Bladder Administration Oral Physiology Kidney Toxicology chemistry.chemical_compound Curcuma Oral administration medicine Animals Oleoresin biology Traditional medicine Plant Extracts business.industry Thyroid Organ Size General Medicine Hyperplasia biology.organism_classification medicine.disease medicine.anatomical_structure Liver chemistry Toxicity Curcumin Female medicine.symptom business Weight gain Food Science |
| Zdroj: | Food and Chemical Toxicology. 23:967-973 |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/0278-6915(85)90245-5 |
| Popis: | Turmeric oleoresin was fed for 102-109 days to groups of eight pigs (males and females) at dietary levels providing intakes of 60, 296 and 1551 mg/kg body weight/day. Twelve pigs served as controls. The highest dose group showed a reduction in weight gain and in food-conversion efficiency. Statistically significant dose-related increases in the weight of the liver and the thyroid were recorded at all dose levels. Pericholangitis, hyperplasia of the thyroid and epithelial changes in the kidney and urinary bladder were observed in the two higher dose groups. It is questionable whether a no-adverse-effect level can be established on the basis of the observations in this experiment. Further studies should be initiated to elucidate the mechanism of action of turmeric. |
| Databáze: | OpenAIRE |
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