Response Surface Methodology as a Useful Tool for Evaluation of the Recovery of the Fluoroquinolones from Plasma—The Study on Applicability of Box-Behnken Design, Central Composite Design and Doehlert Design
| Autor: | Hubert Jarzębski, Andrzej Czyrski |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Analyte
Central composite design Bioengineering 02 engineering and technology lcsh:Chemical technology 01 natural sciences lcsh:Chemistry recovery Chemical Engineering (miscellaneous) Statistical analysis lcsh:TP1-1185 Response surface methodology fluoroquinolones Process engineering Mathematics business.industry Process Chemistry and Technology 010401 analytical chemistry Extraction (chemistry) drug analysis optimization 021001 nanoscience & nanotechnology Box–Behnken design 0104 chemical sciences lcsh:QD1-999 Drug analysis 0210 nano-technology business |
| Zdroj: | Processes; Volume 8; Issue 4; Pages: 473 Processes, Vol 8, Iss 473, p 473 (2020) |
| ISSN: | 2227-9717 |
| DOI: | 10.3390/pr8040473 |
| Popis: | The aim of this study was to find the best design that is suitable for optimizing the recovery of the representatives of the 2nd, 3rd and 4th generation of fluoroquinolones. The following designs were applied: Central Composite Design, Box–Behnken Design and Doehlert Design. The recovery, which was a dependent variable, was estimated for liquid–liquid extraction. The time of shaking, pH, and the volume of the extracting agent (dichloromethane) were the independent variables. All results underwent the statistical analysis (ANOVA), which indicated Central Composite Design as the best model for evaluation of the recovery. For each analyte, an equation was generated that enabled to estimate the theoretical value for the applied conditions. The graphs for these equations were provided by the Response Surface Methodology. The statistical analysis also estimated the most significant factors that have an impact on the liquid–liquid extraction, which occurred to be pH for ciprofloxacin and moxifloxacin and the volume of an extracting solvent for levofloxacin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|