Peripapillary Neovascular Membrane in a Young Pregnant Woman and Prompt Response to Ranibizumab Injections following Uneventful Delivery
| Autor: | Stavros A. Dimitrakos, Konstantinos Anastasilakis, Konstantinos Kaprinis, Asimina Mataftsi, Chrysanthos Symeonidis, Argyrios Tzamalis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Visual acuity Choroidal neovascularization Bevacizumab genetic structures Presumed ocular histoplasmosis syndrome lcsh:Ophthalmology Published: January 2011 Pregnancy Ranibizumab medicine medicine.diagnostic_test business.industry medicine.disease Fluorescein angiography eye diseases Surgery Ophthalmology lcsh:RE1-994 sense organs medicine.symptom Complication business medicine.drug |
| Zdroj: | Case Reports in Ophthalmology Case Reports in Ophthalmology, Vol 2, Iss 1, Pp 129-133 (2011) |
| ISSN: | 1663-2699 |
| Popis: | Purpose: Occurrence of choroidal neovascularization (CNV) during pregnancy has been reported as a complication of presumed ocular histoplasmosis syndrome or punctuate inner chorioretinopathy. To our knowledge, idiopathic CNV (ICNV) during pregnancy has only been reported once in the relevant literature. Bevacizumab has been used for the treatment of ICNV in small case series. However, there is limited experience regarding the use of ranibizumab for the management of ICNV. Case Report: A 31-year-old woman in the eighth month of her second pregnancy was diagnosed with mild macular and papillary edema. She was followed up using biomicroscopy, fluorescein angiography (FA), and optical coherence tomography (OCT). After 3 months, visual acuity further deteriorated and funduscopy, FA and OCT findings revealed a juxtapapillary choroidal neovascular membrane (CNVM). After two ranibizumab injections, best-corrected visual acuity increased significantly, physiological macular anatomy was restored and no subretinal fluid was observed. Discussion: In this case report, we present a young pregnant patient with peripapillary ICNV and neurosensory detachment involving the macula, and treatment of the eye with intravitreal ranibizumab following uneventful delivery. Increased angiogenic factor levels associated with pregnancy may contribute to the onset of CNV although this relationship has to be investigated experimentally. The rapid response to ranibizumab suggests that this anti-VEGF agent may be an alternative treatment option in the management of peripapillary ICNV. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|