Determination of tissue–blood partition coefficients for a physiological model for humans, and estimation of dioxin concentration in tissues
| Autor: | Wakae Maruyama, Kikuo Yoshida, Junko Nakanishi, Takayuki Tanaka |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Liver chemistry
Food intake Physiologically based pharmacokinetic modelling Polychlorinated Dibenzodioxins Environmental Engineering Health Toxicology and Mutagenesis Adipose tissue Kidney Pharmacokinetics Humans Soil Pollutants Environmental Chemistry Tissue Distribution Muscle Skeletal Chromatography Chemistry Public Health Environmental and Occupational Health General Medicine General Chemistry Models Theoretical Polychlorinated Biphenyls Pollution Partition coefficient Physiological model Liver Environmental chemistry Environmental Pollutants Polychlorinated dibenzofurans |
| Zdroj: | Chemosphere. 46:975-985 |
| ISSN: | 0045-6535 |
| DOI: | 10.1016/s0045-6535(01)00208-9 |
| Popis: | The tissue-blood partition coefficients for a physiologically based pharmacokinetic (PBPK) model were determined, and the concentrations of 17 congeners of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) in tissues in Japanese people were estimated using the model. According to the PBPK model established by Lawrence and Gobas [Chemosphere 35 (1997) 427-452], we assumed a steady-state fugacity model for Japanese people in general, and set the route of PCDD/Fs exposure only from food intake. The required partition coefficients for liver, kidney, adipose, muscle, skin, bile, gut and viscera (richly perfused tissue) were calculated using available autopsy data from eight Japanese men and women who were not accidentally exposed to PCDD/Fs. For validation of the partition coefficients, estimated PCDD/F concentrations in liver, kidney, fat, blood and muscle using the model were compared to other two sets of measured concentration data in Japanese tissues. Good agreement was obtained between estimated data and measured data, and most of the measured data were within the simulated concentration range in liver, kidney, blood and muscle. From these results, our model and calculated partition coefficients seem applicable for the estimation of congener-specific concentrations in human tissues. |
| Databáze: | OpenAIRE |
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