PROGNOSTIC IMPACT OF NEUTROPHILS-TO-LYMPHOCYTES RATIO (NLR), PD-L1 EXPRESSION, AND TUMOR IMMUNE MICROENVIRONMENT IN LARYNGEAL CANCER
| Autor: | Lara Alessandrini, Leonardo Franz, Alessandro Carli, Elena Fasanaro, Piero Nicolai, Gino Marioni, Piergiorgio Gaudioso |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male Pathology medicine.medical_specialty Neutrophils Immune microenvironment medicine.medical_treatment B7-H1 Antigen Disease-Free Survival Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Immune system Lymphocytes Tumor-Infiltrating PD-L1 Preoperative Care medicine Carcinoma Tumor Microenvironment Humans Lymphocytes Laryngeal Neoplasms Aged Neoplasm Staging Retrospective Studies Tumor microenvironment biology business.industry Cancer General Medicine Immunotherapy Middle Aged medicine.disease Prognosis Immunohistochemistry 030104 developmental biology 030220 oncology & carcinogenesis Cancer cell biology.protein Cancer research Female business Follow-Up Studies |
| Popis: | Purpose In laryngeal carcinoma (LSCC), tumor immune microenvironment is attracting increasing interest, given the recent progresses in immunotherapy. Immune cells migrate to tumors as a result of a tumor antigen-induced immune reaction and cancer cells recruit immune regulatory cells to induce an immunosuppressive network, resulting in the escape from host immunity. This interaction reflects both on tumor microenvironment and systemic inflammatory status. Blood neutrophil-to-lymphocyte ratio (NLR), reflecting a highly pro-inflammatory status, has been related to worse oncological survival outcomes. The aim of this study was to analyze in LSCC the relationship between circulating inflammatory cells (also in terms of NLR) and tumor immune microenvironment histopathological features (programmed cell death ligand 1 [PD-L1] expression, and tumor-infiltrating lymphocytes [TILs]), also investigating their clinical-pathological and prognostic significance. Methods Blood pre-operative NLR, and, at pathology, PD-L1 (in terms of combined positive score [CPS]) and TILs were assessed on 60 consecutive cases of LSCC. Results Blood NLR, neutrophils, and lymphocytes counts showed a significant value in predicting DFS and recurrence risk. Moreover, PD-L1 CPS ≥ 1 and TILs count rate ≥30% were associated with higher disease-free survival (DFS) and reduced recurrence risk. A logistic regression model found a significant positive association between increasing NLR values, and PD-L1 CPS Conclusions Further studies are needed to better characterize the role of pre-operative blood NLR in association with PD-L1 expression and tumor immune microenvironment features as prognostic factors and markers of anti-tumor immune response in LSCCs, also with regard to the effectiveness of immunotherapeutic protocols. |
| Databáze: | OpenAIRE |
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