Clinicopathologic retrospective analysis of blastic plasmacytoid dendritic cell neoplasms
| Autor: | Waldemar Placek, Anna Kowalczyk, Zygmunt Kozielec, Berenika Olszewska, Marta Malek, Grażyna Poniatowska-Broniek, Wanda Knopinska-Posluszny, Wojciech Biernat, Małgorzata Sokołowska-Wojdyło, Roman Nowicki, Aleksandra Znajewska-Pander, Agnieszka Owczarczyk-Saczonek |
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| Rok vydání: | 2018 |
| Předmět: |
Review Paper
medicine.medical_specialty business.industry Incidence (epidemiology) blastic plasmacytoid dendritic cell neoplasm Dermatology Blastic plasmacytoid dendritic cell neoplasm Disease Plasmacytoid dendritic cell 030204 cardiovascular system & hematology Malignancy medicine.disease CD4 Disease course 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Retrospective analysis Immunology and Allergy Medicine CD56 business Who classification |
| Zdroj: | Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii |
| ISSN: | 1642-395X |
| DOI: | 10.5114/ada.2017.72269 |
| Popis: | Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is one of the aggressive rare hematopoietic malignancies with predilection to the skin, primarily found in adults. The precise incidence of BPDCN is difficult to estimate due to constantly changing nomenclature and lack of precise defining criteria prior to the 2008 WHO classification system. There are not many cases described in the literature, what makes the diagnostic process challenging. Skin lesions such as erythematous infiltrates and nodules are usually the first manifestation of the disease. Therefore, in doubtful diagnostic cases, dermatologists should perform histopathological and immunohistochemistry examinations along with hematological and oncological cooperation, as early diagnosis and appropriate treatment is essential for improvement of the disease course. This analysis, despite the small number of patients may provide useful information on the clinical and histopathological features of this rare malignancy. |
| Databáze: | OpenAIRE |
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