Factors Affecting the Loss of Carbon Monoxide from Stored Blood Samples*
| Autor: | Leo R. Goldbaum, Donald H. Chace, Nicholas T. Lappas |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Nitrogen
Surface Properties Health Toxicology and Mutagenesis Blood preservation Mineralogy Toxicology Biological fluid Analytical Chemistry Carbon Monoxide Poisoning Hemoglobins chemistry.chemical_compound Animal science Drug Stability Humans Environmental Chemistry Whole blood Chemical Health and Safety Air Temperature Oxygen Carboxyhemoglobin chemistry Blood Preservation Postmortem Changes Hemoglobin Saturation (chemistry) Carbon monoxide |
| Zdroj: | Journal of Analytical Toxicology. 10:181-189 |
| ISSN: | 1945-2403 0146-4760 |
| DOI: | 10.1093/jat/10.5.181 |
| Popis: | The loss of carbon monoxide (CO) from whole blood or hemolysates has been investigated. Blood samples were exposed to the atmosphere or to a limited volume of air for various storage periods at three temperatures. The initial hemoglobin (Hb) concentration and the percent carboxyhemoglobin (%COHb) saturation were varied in separate experiments. In addition, the effect of repeated exposure of blood to air was evaluated. The %COHb saturation decreased from 80 to 50% following storage of a 1-mL blood sample with 49 mL of air in a sealed container at room temperature for 45 hr. Greater decreases in the %COHb saturation were observed in samples which were exposed to the atmosphere. Lesser, but significant, losses occurred when samples were stored in a refrigerator or freezer. The concentration of Hb in the samples as well as the initial %COHb saturation were found to influence the decrease in the %COHb saturation. |
| Databáze: | OpenAIRE |
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