Transferrin receptor 1 is a cellular receptor for human heme-albumin
| Autor: | Raif S. Geha, Janet Chou, Hannes Stockinger, Verena Berg, Maria Seyerl-Jiresch, Akihiro Yachie, Alexander Puck, Peter Steinberger, Gerhard J. Zlabinger, Hyeryun Choe, Sarojinidevi Künig, Madhura Modak, Markus Kraller, Brell Jennifer, Leopold Öhler, Johannes Stöckl |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cell type Cell biology Molecular biology Iron Medicine (miscellaneous) Transferrin receptor Endocytosis General Biochemistry Genetics and Molecular Biology Article Cell Line 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Antigens CD Albumins Receptors Transferrin Humans Scavenger receptor Heme lcsh:QH301-705.5 Cell Proliferation chemistry.chemical_classification Biological Transport Ligand (biochemistry) Culture Media 030104 developmental biology chemistry Gene Expression Regulation lcsh:Biology (General) Transferrin 030220 oncology & carcinogenesis General Agricultural and Biological Sciences Intracellular Heme Oxygenase-1 |
| Zdroj: | Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020) Communications Biology |
| ISSN: | 2399-3642 |
| DOI: | 10.1038/s42003-020-01294-5 |
| Popis: | Iron is essential for living cells. Uptake of iron-loaded transferrin by the transferrin receptor 1 (CD71, TFR) is a major but not sufficient mechanism and an alternative iron-loaded ligand for CD71 has been assumed. Here, we demonstrate that CD71 utilizes heme-albumin as cargo to transport iron into human cells. Binding and endocytosis of heme-albumin via CD71 was sufficient to promote proliferation of various cell types in the absence of transferrin. Growth and differentiation of cells induced by heme-albumin was dependent on heme-oxygenase 1 (HO-1) function and was accompanied with an increase of the intracellular labile iron pool (LIP). Import of heme-albumin via CD71 was further found to contribute to the efficacy of albumin-based drugs such as the chemotherapeutic Abraxane. Thus, heme-albumin/CD71 interaction is a novel route to transport nutrients or drugs into cells and adds to the emerging function of CD71 as a scavenger receptor. Brell, Berg et al find that iron enters cells not only through iron-transferrin uptake by the transferrin receptor (CD71) but also through uptake of heme-albumin by this receptor and that heme-albumin stimulates proliferation in a manner dependent on heme oxygenase 1. This study presents a new route for iron uptake in mammalian cells. |
| Databáze: | OpenAIRE |
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