MicroRNA networks direct neuronal development and plasticity
| Autor: | N.F.M. Olde Loohuis, H Van Bokhoven, Nael Nadif Kasri, Aron Kos, Armaz Aschrafi, Gerard J.M. Martens |
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| Jazyk: | angličtina |
| Předmět: |
Neurite
DCN MP - Plasticity and memory Neurogenesis Review Biology Models Biological Learning and memory Synapse 03 medical and health sciences Mice Cellular and Molecular Neuroscience 0302 clinical medicine Gene expression microRNA Neuroplasticity Animals Humans Molecular Biology 030304 developmental biology Regulation of gene expression Neurons Pharmacology 0303 health sciences Neuronal Plasticity Molecular Animal Physiology Brain MicroRNA Cell Biology Genetics and epigenetic pathways of disease DCN MP - Plasticity and memory [NCMLS 6] Cell biology Rats MicroRNAs Gene Expression Regulation Protein Biosynthesis Synaptic plasticity Neuronal development Molecular Medicine Nervous System Diseases 030217 neurology & neurosurgery Neurological diseases |
| Zdroj: | Cellular and Molecular Life Sciences Cellular and Molecular Life Sciences, 69, 89-102 Cellular and Molecular Life Sciences, 69, 1, pp. 89-102 Cellular and Molecular Life Sciences; Vol 69 |
| ISSN: | 1420-682X |
| DOI: | 10.1007/s00018-011-0788-1 |
| Popis: | Contains fulltext : 108666.pdf (Publisher’s version ) (Open Access) MicroRNAs (miRNAs) constitute a class of small, non-coding RNAs that act as post-transcriptional regulators of gene expression. In neurons, the functions of individual miRNAs are just beginning to emerge, and recent studies have elucidated roles for neural miRNAs at various stages of neuronal development and maturation, including neurite outgrowth, dendritogenesis, and spine formation. Notably, miRNAs regulate mRNA translation locally in the axosomal and synaptodendritic compartments, and thereby contribute to the dynamic spatial organization of axonal and dendritic structures and their function. Given the critical role for miRNAs in regulating early brain development and in mediating synaptic plasticity later in life, it is tempting to speculate that the pathology of neurological disorders is affected by altered expression or functioning of miRNAs. Here we provide an overview of recently identified mechanisms of neuronal development and plasticity involving miRNAs, and the consequences of miRNA dysregulation. |
| Databáze: | OpenAIRE |
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