The contact system—a novel branch of innate immunity generating antibacterial peptides
| Autor: | Lars Björck, Dorit K. Nägler, Per Åkesson, Matthias Mörgelin, Inga-Maria Frick, Martin Malmsten, Heiko Herwald |
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| Rok vydání: | 2006 |
| Předmět: |
Kininogen
High-Molecular-Weight High-molecular-weight kininogen Molecular Sequence Data Peptide Biology Article General Biochemistry Genetics and Molecular Biology Microbiology Mice Protein structure Animals Humans Amino Acid Sequence Molecular Biology Peptide sequence chemistry.chemical_classification Kininogen Innate immune system Bacteria General Immunology and Microbiology General Neuroscience Immunity Innate Anti-Bacterial Agents Protein Structure Tertiary Cell biology Amino acid chemistry Peptides Antibacterial activity |
| Zdroj: | The EMBO Journal. 25:5569-5578 |
| ISSN: | 1460-2075 0261-4189 |
| Popis: | Activation of the contact system has two classical consequences: initiation of the intrinsic pathway of coagulation, and cleavage of high molecular weight kininogen (HK) leading to the release of bradykinin, a potent proinflammatory peptide. In human plasma, activation of the contact system at the surface of significant bacterial pathogens was found to result in further HK processing and bacterial killing. A fragment comprising the D3 domain of HK is generated, and within this fragment a sequence of 26 amino acids is mainly responsible for the antibacterial activity. A synthetic peptide covering this sequence kills several bacterial species, also at physiological salt concentration, as effectively as the classical human antibacterial peptide LL-37. Moreover, in an animal model of infection, inhibition of the contact system promotes bacterial dissemination and growth. These data identify a novel and important role for the contact system in the defence against invasive bacterial infection. |
| Databáze: | OpenAIRE |
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