Circulating luteinizing hormone level after triggering oocyte maturation with GnRH agonist may predict oocyte yield in flexible GnRH antagonist protocol
| Autor: | Hai-Yan Zheng, Xin Chen, Yu-Xia He, De-Sheng Ye, Xin-Hong Yang, Yan Tang, Wei Guo, Shi-Ling Chen |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Agonist medicine.medical_specialty Pregnancy Rate medicine.drug_class media_common.quotation_subject Ovarian hyperstimulation syndrome Gonadotropin-releasing hormone antagonist Gonadotropin-Releasing Hormone Ovarian Hyperstimulation Syndrome Human fertilization Ovulation Induction Pregnancy Risk Factors Internal medicine medicine Humans Prospective Studies Ovulation media_common business.industry Rehabilitation Pregnancy Outcome Obstetrics and Gynecology Luteinizing Hormone medicine.disease Oocyte Pregnancy rate Treatment Outcome Endocrinology medicine.anatomical_structure Reproductive Medicine Oocytes Female Gonadotropin business |
| Zdroj: | Human Reproduction. 27:1351-1356 |
| ISSN: | 1460-2350 0268-1161 |
| DOI: | 10.1093/humrep/des049 |
| Popis: | The use of gonadotrophin-releasing hormone (GnRH) agonist for triggering final oocyte maturation and ovulation can reduce ovarian hyperstimulation syndrome (OHSS) in high-risk patients. LH levels post-trigger with GnRH agonist might be correlated with oocyte yield and maturity. Our aim was to evaluate the relationship between serum LH level at 12-h post-trigger and oocyte yield, maturity and fertilization rate in patients at high risk of OHSS and therefore who were treated with a flexible GnRH antagonist protocol in which final oocyte maturation was triggered with GnRH agonist.In a prospective cohort study, 91 patients at high risk of OHSS were treated with a flexible GnRH antagonist protocol and divided into six groups according to their serum LH levels at 12-h after GnRH agonist administration: ≤15.0, 15.1-30.0, 30.1-45.0, 45.1-60.0, 60.1-75.0 and75.0 IU/l. The oocyte yield, maturity, fertilization rate and clinical outcomes for each LH interval were analyzed.There was a statistically significant reduction in oocyte yield with a concentration of serum LH ≤15.0 IU/l (P0.05), whereas no statistically significant differences in the oocyte maturity and fertilization rate among the six groups (P0.05) were seen. Only 5 out of 91 patients (5.5%) had a serum LH ≤15.0 IU/l at 12-h post-trigger with GnRH agonist. In addition, no statistically significant difference was seen regarding high-quality embryos, implantation rate, clinical pregnancy rate and early miscarriage between patients with LH ≤15.0 IU/l and15.0 IU/l (P0.05).Serum LH level at 12-h post-trigger with GnRHa15.0 IU/l is associated with a dramatically lower oocyte yield but not with the oocyte maturity and fertilization rate. Serum LH levels post-trigger with GnRH agonist do not affect clinical outcomes. |
| Databáze: | OpenAIRE |
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