Utilization rates and results of long-term embryo cryopreservation before gonadotoxic treatment
| Autor: | S. Hollanders de Ouderaen, Céline Pirard, Dominique Demylle, Marie-Madeleine Dolmans |
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| Přispěvatelé: | UCL - SSS/IREC/GYNE - Pôle de Gynécologie, UCL - (SLuc) Centre de thérapie tissulaire et cellulaire, UCL - (SLuc) Service de gynécologie et d'andrologie |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Oncology medicine.medical_specialty animal structures Pregnancy Rate Context (language use) Fertilization in Vitro Thawing Biology Cryopreservation Embryo banking Andrology Young Adult Ovulation Induction Embryo cryopreservation Pregnancy Neoplasms Internal medicine Genetics medicine Humans In patient Fertility preservation Genetics (clinical) Retrospective Studies Pregnancy Outcome Fertility Preservation Obstetrics and Gynecology Neoplasms therapy Cancer patients General Medicine Embryo Transfer Pregnancy rate Blastocyst Reproductive Medicine IVF embryonic structures Female Utilization rate Developmental Biology |
| Zdroj: | Journal of Assisted Reproduction and Genetics, Vol. 32, no. 8, p. 1233-1237 (2015) |
| ISSN: | 1573-7330 1058-0468 |
| DOI: | 10.1007/s10815-015-0533-z |
| Popis: | Purpose: The aim of this study was to evaluate long-term embryo cryopreservation, utilization, and success rate in patients subjected to gonadotoxic treatments in the context of cancer. Methods: This is a retrospective study on patients (n = 54) undergoing ovarian stimulation and IVF for fertility preservation between January 1997 and June 2014. Embryos were slow-frozen and stored until the women were cured and able to undergo embryo transfer. Results: Fifty-four women underwent 66 oocyte pick-up procedures in total, and embryos were obtained from 52 of the 54 patients. Four patients died before their frozen embryos could be thawed. Of the remaining 48, 9 women returned to use their embryos, resulting in 6 pregnancies (66 % cumulative pregnancy rate), two of which ended in miscarriage. The live birth rate per patient was thus 44 % (4/9). The true come-back rate, calculated after applicable exclusions, was found to be 23 %. Conclusion: IVF followed by embryo freezing is a widely established technique for fertility preservation, but little has been published on the outcomes in cancer patients. While we found the number of good-quality embryos to be lower than in a normal population, the cumulative live birth rate was similar to that achieved with fresh embryos in non-cancer patients. The utilization rate of this fertility preservation method can be considered high. |
| Databáze: | OpenAIRE |
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