Outcome in a hepatitis C (genotype 1b) single source outbreak in Germany—a 25-year multicenter study
| Autor: | Wolfgang Güthoff, Michael Lafrenz, Kurt Grüngreiff, Heiner Porst, Manfred Wiese, U. Oesen |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Carcinoma Hepatocellular Cirrhosis Alcohol Drinking Genotype Hepatitis C virus Hepacivirus medicine.disease_cause Disease Outbreaks Flaviviridae Risk Factors Germany Internal medicine medicine Humans Age of Onset Hepatology biology business.industry Liver Neoplasms Hepatitis C Middle Aged Viral Load medicine.disease biology.organism_classification Comorbidity Immunology Cohort Female business Viral load |
| Zdroj: | Journal of Hepatology. 43:590-598 |
| ISSN: | 0168-8278 |
| DOI: | 10.1016/j.jhep.2005.04.007 |
| Popis: | Background/Aims The natural course of the hepatitis C virus genotype 1b (HCV-1b) infection is still unclear but important for therapeutic decisions. There are few unbiased long-term follow-up studies with known dates of infection. Methods Between August 1978 and March 1979, 14 HCV-1b contaminated batches of anti-D immunoglobulin had been administered to 2867 women for prophylaxis of rhesus isoimmunization throughout East Germany. We reexamined 1980 women, representing 70% of the total cohort of 15 centers. Results After application of the contaminated anti-D, 93% of the recipients developed an acute hepatitis C. After 25 years, 86% of the 1833 affected women still tested positive for hepatitis C virus antibodies and 46% for HCV RNA. Only nine (0.5%) had overt liver cirrhosis, 30 women (1.5%) developed precirrhotic stages and one HCC was diagnosed. Ten (0.5%) died of HCV related complications, half of these related to additional comorbidity. In the last 5 years, a continuous, but low increase of fibrotic scores was observed. Conclusions Young women without comorbidity may clear HCV (1b) infection in more than half of the cases, or develop mild chronic hepatitis C. We confirmed the low risk of progression to cirrhosis in this cohort within 25 years. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect