New antimicrobial contact catalyst killing antibiotic resistant clinical and waterborne pathogens
| Autor: | Itziar Alkorta, Melanie Broszat, C. Meyer, A. Guridi, M. Garcia-Moreno, E. Clauss-Lendzian, W. Schmieder, U. Landau, R. Blasi, R. Andrade, Sandra Águila-Arcos, Elisabeth Grohmann, Ann-Kristin Diederich, T. Sakinc-Gueler |
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| Rok vydání: | 2014 |
| Předmět: |
Silver
Colony Count Microbial Bioengineering Microbial Sensitivity Tests medicine.disease_cause Enterococcus faecalis Catalysis Microbiology Biomaterials Antibiotic resistance Staphylococcus epidermidis Water Supply Waterborne Diseases medicine Humans Microbial Viability biology Bacteria Spectrometry X-Ray Emission Drug Resistance Microbial biochemical phenomena metabolism and nutrition biology.organism_classification Antimicrobial Anti-Bacterial Agents Disinfection Mechanics of Materials Staphylococcus aureus Batch Cell Culture Techniques Antimicrobial surface Water Microbiology Staphylococcus Enterococcus faecium |
| Zdroj: | Materials scienceengineering. C, Materials for biological applications. 50 |
| ISSN: | 1873-0191 |
| Popis: | Microbial growth on medical and technical devices is a big health issue, particularly when microorganisms aggregate to form biofilms. Moreover, the occurrence of antibiotic-resistant bacteria in the clinical environment is dramatically growing, making treatment of bacterial infections very challenging. In search of an alternative, we studied a novel antimicrobial surface coating based on micro galvanic elements formed by silver and ruthenium with surface catalytic properties. The antimicrobial coating efficiently inhibited the growth of the nosocomial pathogens Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis and Enterococcus faecium as demonstrated by the growth inhibition on agar surface and in biofilms of antibiotic resistant clinical E. faecalis, E. faecium, and S. aureus isolates. It also strongly reduced the growth of Legionella in a drinking water pipeline and of Escherichia coli in urine. We postulate a mode of action of the antimicrobial material, which is independent of the release of silver ions. Thus, the novel antimicrobial coating could represent an alternative to combat microbial growth avoiding the toxic side effects of high levels of silver ions on eukaryotic cells. |
| Databáze: | OpenAIRE |
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