Microbiological laboratory diagnostics of neglected zoonotic diseases (NZDs)
| Autor: | Norbert Georg Schwarz, Daniel Eibach, Andreas Hahn, Ulrike Loderstaedt, Andreas E. Zautner, M. Fischer, Ralf Matthias Hagen, Hagen Frickmann, Rebecca Hinz |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Veterinary medicine Neglected zoonotic disease NZD Neglected tropical disease Laboratory Diagnostic Serology PCR Molecular diagnosis Culture Sensitivity Specificity Reliability Veterinary (miscellaneous) 030231 tropical medicine 030106 microbiology Sensitivity and Specificity 03 medical and health sciences 0302 clinical medicine Zoonoses Medicine Taeniasis Animals Humans Serologic Tests Intensive care medicine Microscopy biology business.industry Clinical Laboratory Techniques Neglected Diseases Reproducibility of Results Brucellosis Cysticercosis medicine.disease biology.organism_classification Echinococcosis 3. Good health Infectious Diseases Molecular Diagnostic Techniques Insect Science Spectrometry Mass Matrix-Assisted Laser Desorption-Ionization Taenia Parasitology Rabies Cattle business Trypanosomiasis |
| Zdroj: | Acta tropica. 165 |
| ISSN: | 1873-6254 |
| Popis: | tThis review reports on laboratory diagnostic approaches for selected, highly pathogenic neglectedzoonotic diseases, i.e. anthrax, bovine tuberculosis, brucellosis, echinococcosis, leishmaniasis, rabies,Taenia solium-associated diseases (neuro-/cysticercosis & taeniasis) and trypanosomiasis.Diagnostic options, including microscopy, culture, matrix-assisted laser-desorption-ionisation time-of-flight mass spectrometry, molecular approaches and serology are introduced. These procedures arecritically discussed regarding their diagnostic reliability and state of evaluation. For rare diseases reliableevaluation data are scarce due to the rarity of samples.If bio-safety level 3 is required for cultural growth, but such high standards of laboratory infrastruc-ture are not available, serological and molecular approaches from inactivated sample material might bealternatives.Multiple subsequent testing using various test platforms in a stepwise approach may improve sensi-tivity and specificity.Cheap and easy to use tests, usually called “rapid diagnostic tests” (RDTs) may impact disease controlmeasures, but should not preclude developing countries from state of the art diagnostics.© 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license peerReviewed |
| Databáze: | OpenAIRE |
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