CSF protein panels reflecting multiple pathophysiological mechanisms for early and specific diagnosis of Alzheimer’s disease
| Autor: | Del Campo, M., Peeters, C.F.W., Johnson, E.C.B., Vermunt, L., Hok-A-Hin, Y.S., van Nee, M., Chen-Plotkin, A., Hu, W.T., Lah, J.J., Seyfried, N.T., Herradon, G., Meeter, L.H.H., van Swieten, J.C., Levey, A.I., Lemstra, A.W., Pijnenburg, Y.A.L., Visser, P.J., Tijms, B.M., van der Flier, W.M., Teunissen, C.E. |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Alzheimer's and Dementia 17 (2021) S5 Alzheimer's and Dementia, 17(S5) |
| ISSN: | 1552-5260 |
| Popis: | BackgroundThe development of disease-modifying therapies against Alzheimer’s disease (AD) requires biomarker panels that reflect the diverse pathological pathways specifically involved in AD. Here we aimed to identify and validate panels of cerebrospinal fluid (CSF) proteins covering different molecular pathways for early and specific diagnosis of AD.MethodWe measured 665 proteins in 797 CSF samples from patients with mild cognitive impairment with abnormal amyloid (MCI(Aβ+): n=50), AD-dementia (n=230), non-AD dementias (n=322; 123 DLB and 199 FTD) and cognitively-unimpaired controls (n=195; classical AD CSF biomarkers negative) using proximity ligation-based multiplex immunoassays. Nested and penalized linear modeling were used to identify protein differences (q |
| Databáze: | OpenAIRE |
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