Acute uncomplicated lower urinary tract infections in general practice: clinical and microbiological cure rates after three- versus five-day treatment with trimethoprim
| Autor: | Inge Raets, S. Nys, Tiny van Merode, Ellen E. Stobberingh |
|---|---|
| Přispěvatelé: | Huisartsgeneeskunde, Medische Microbiologie, RS: NUTRIM School of Nutrition and Translational Research in Metabolism |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors Adolescent Urinary system Anti-Infective Agents Urinary Trimethoprim Persistence (computer science) law.invention Randomized controlled trial law Surveys and Questionnaires Internal medicine Epidemiology Escherichia coli medicine Humans Proteus mirabilis Aged business.industry Enterobacteriaceae Infections Bacteriological Cure Middle Aged Surgery Regimen Treatment Outcome Acute Disease Urinary Tract Infections General practice Female Family Practice business medicine.drug |
| Zdroj: | European Journal of General Practice, 11(2), 55-58. Routledge/Taylor & Francis Group |
| ISSN: | 1751-1402 1381-4788 |
| Popis: | OBJECTIVES: Epidemiological studies indicate that acute uncomplicated urinary tract infections (UTI) in women can be successfully treated with short treatment regimens. However, the findings from the literature do not match experiences in daily practice. METHODS: A randomised, controlled trial evaluating the microbiological and clinical (self-reported) cure rates of a three-day vs. five-day treatment regimen with trimethoprim for UTI in women. RESULTS: No statistically significant difference in bacteriological cure rate was found between the three-day and five-day regimen. One day after the shorter regimen 44% of women considered themselves as 'not-recovered' due to persistence of the symptoms compared with 35% after the five-day treatment (p > 0.05). Three days after therapy these percentages were 30 and 25% respectively. CONCLUSION: The relatively high percentage of persistent symptoms one day after the three-day regimen might be responsible for general practitioners believing that short regimens are not successful. It is therefore advisable that if urine samples are controlled to wait at least three days after finishing treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|