Ru(TAP)32+ uses multivalent binding to accelerate and constrain photo-adduct formation on DNA

Autor:	Carola Lampe, Pauline J. Kolbeck, Thomas Nicolaus, Jan Lipfert, Willem Vanderlinden, Wout Frederickx, Alexander S. Urban, Cécile Moucheron, Sebastian F. Konrad
Rok vydání:	2019
Předmět:	Guanine Light Physique de l'état solide Ligands 010402 general chemistry Photochemistry 01 natural sciences Ruthenium Catalysis Chimie des solides Adduct Nucleobase DNA Adducts Electron transfer chemistry.chemical_compound Organometallic Compounds Materials Chemistry Chimie Molecule 010405 organic chemistry Metals and Alloys DNA Métallurgie General Chemistry Phenanthrenes Intercalating Agents 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry Ceramics and Composites Nucleic Acid Conformation Multivalent binding Catalyses hétérogène et homogène Excitation Phenanthrolines
Zdroj:	Chemical communications, 55 (60
ISSN:	1364-548X 1359-7345
DOI:	10.1039/c9cc02838b
Popis:	Ru(ii)-complexes with polyazaaromatic ligands can undergo direct electron transfer with guanine nucleobases on blue light excitation that results in DNA lesions with phototherapeutic potential. Here we use single molecule approaches to demonstrate DNA binding mode heterogeneity and evaluate how multivalent binding governs the photochemistry of [Ru(TAP)3]2+ (TAP = 1,4,5,8-tetraazaphenanthrene). SCOPUS: ar.j info:eu-repo/semantics/published
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6bef9ff25d0c2d317ed53cf97c99ac6 https://doi.org/10.1039/c9cc02838b Zobrazit plný text záznamu