Structure-based design and biochemical evaluation of sulfanilamide derivatives as hepatitis B virus capsid assembly inhibitors
| Autor: | Sung-Gyoo Park, Jin-Su Song, Guhung Jung, Hie-Joon Kim, Min-Hyung Cho |
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| Rok vydání: | 2012 |
| Předmět: |
Models
Molecular Hepatitis B virus viruses Drug design Biology medicine.disease_cause Capsid Sulfanilamide Protein structure In vivo Sulfanilamides Drug Discovery medicine Pharmacology Molecular Structure Virus Assembly General Medicine biochemical phenomena metabolism and nutrition Virology In vitro Biochemistry Drug Design Structure based medicine.drug |
| Zdroj: | Journal of Enzyme Inhibition and Medicinal Chemistry. 28:916-925 |
| ISSN: | 1475-6374 1475-6366 |
| Popis: | Virus capsid structure is essential in virion maturation and durability, so disrupting capsid assembly could be an effective way to reduce virion count and cure viral diseases. However, currently there is no known antiviral which affects capsid inhibition, and only a small number of assembly inhibitors were experimentally successful. In this present study, we aimed to find hepatitis B virus (HBV) capsid assembly inhibitor which binds to the HBV core protein and changes protein conformation. Several candidate molecules were found to bind to certain structure in core protein with high specificity. Furthermore, these molecules significantly changed the protein conformation and reduced assembly affinity of core protein, leading to decrease of the number of assembled capsid or virion, both in vitro and in vivo. In addition, prediction also suggests that improvements in inhibition efficiency could be possible by changing functional groups and ring structures. |
| Databáze: | OpenAIRE |
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