Salivary and serum interleukin-6 levels in proliferative verrucous leukoplakia
| Autor: | Leticia Bagan, Guillermo T. Sáez, M. Carmen Tormos, Jose V. Bagan, Judith Murillo-Cortes, Carlos Labaig-Rueda |
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| Rok vydání: | 2014 |
| Předmět: |
Saliva
Pathology medicine.medical_specialty Chemokine 03 medical and health sciences 0302 clinical medicine Carcinoma medicine Humans Interleukin 6 General Dentistry Leukoplakia Mouth neoplasm biology business.industry Interleukin-6 Case-control study Interleukin 030206 dentistry medicine.disease stomatognathic diseases 030220 oncology & carcinogenesis Case-Control Studies biology.protein Carcinoma Squamous Cell Mouth Neoplasms Leukoplakia Oral Neoplasm Recurrence Local business |
| Zdroj: | Clinical oral investigations. 20(4) |
| ISSN: | 1436-3771 |
| Popis: | Cytokines and chemokines have been analysed in patients with oral squamous cell carcinoma and potentially malignant disorders. We selected interleukin-6 (IL-6) because it is a multifunctional interleukin reported to be altered in potentially malignant oral disorders and in malignant lesions. To date, this has not been evaluated or tested in proliferative verrucous leukoplakia (PVL), however. This study aimed to analyse the differences in serum and saliva IL-6 levels among patients with PVL, oral squamous cell carcinoma (OSCC) and healthy controls and to examine the relationship between salivary IL-6 levels and the extent of the verrucous area. Using an enzyme-linked immunosorbent assay, we determined the serum and saliva IL-6 levels in three groups: 20 patients with PVL, 20 with OSCC and 20 healthy controls. There were significant (p |
| Databáze: | OpenAIRE |
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