Broadly Tuned Response Properties of Diverse Inhibitory Neuron Subtypes in Mouse Visual Cortex
| Autor: | Aaron M. Kerlin, R. Clay Reid, Vladimir K. Berezovskii, Mark L. Andermann |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
0303 health sciences
Neuroscience(all) General Neuroscience Sensory system Visual system Biology Stimulus (physiology) Article 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Calcium imaging Visual cortex nervous system medicine biology.protein GABAergic Sensory cortex Neuroscience 030217 neurology & neurosurgery Parvalbumin 030304 developmental biology |
| Zdroj: | Neuron. 67:858-871 |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/j.neuron.2010.08.002 |
| Popis: | SummaryDifferent subtypes of GABAergic neurons in sensory cortex exhibit diverse morphology, histochemical markers, and patterns of connectivity. These subtypes likely play distinct roles in cortical function, but their in vivo response properties remain unclear. We used in vivo calcium imaging, combined with immunohistochemical and genetic labels, to record visual responses in excitatory neurons and up to three distinct subtypes of GABAergic neurons (immunoreactive for parvalbumin, somatostatin, or vasoactive intestinal peptide) in layer 2/3 of mouse visual cortex. Excitatory neurons had sharp response selectivity for stimulus orientation and spatial frequency, while all GABAergic subtypes had broader selectivity. Further, bias in the responses of GABAergic neurons toward particular orientations or spatial frequencies tended to reflect net biases of the surrounding neurons. These results suggest that the sensory responses of layer 2/3 GABAergic neurons reflect the pooled activity of the surrounding population—a principle that may generalize across species and sensory modalities. |
| Databáze: | OpenAIRE |
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