Oxidised fish oil does not influence established markers of oxidative stress in healthy human subjects: a randomised controlled trial
| Autor: | Berit Nordvi, Inger Ottestad, Kirsten B. Holven, Stine Marie Ulven, Kjetil Retterstøl, Gjermund Vogt, Kirsti W. Brønner, John-Erik Haugen, Astrid Nilsson, Lene Frost Andersen, Mari C. W. Myhrstad, Gitte Ravn-Haren |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Antioxidant food.ingredient Erythrocytes Patient Dropouts medicine.medical_treatment Urinary system Medisinske Fag: 700::Helsefag: 800::Ernæring: 811 [VDP] alpha-Tocopherol Medicine (miscellaneous) Cod Liver Oil Inflammation Biology medicine.disease_cause Dinoprost Lipid peroxidation VDP::Medisinske Fag: 700::Helsefag: 800::Ernæring: 811 chemistry.chemical_compound Young Adult food Double-Blind Method Fatty Acids Omega-3 medicine Humans Food science Morning Aldehydes Nutrition and Dietetics Norway Sunflower oil Fish oil Oxidative Stress Fiskeolje C-Reactive Protein Biochemistry chemistry Omega-3 fettsyrer Folkehelse Dietary Supplements Female Lipid Peroxidation medicine.symptom Oxidoreductases Oxidation-Reduction Oxidative stress Biomarkers |
| Zdroj: | The British journal of nutrition. 108(2) |
| ISSN: | 1475-2662 |
| Popis: | Intake of fish oil reduces the risk of CHD and CHD deaths. Marine n-3 fatty acids (FA) are susceptible to oxidation, but to our knowledge, the health effects of intake of oxidised fish oil have not previously been investigated in human subjects. The aim of the present study was to investigate markers of oxidative stress, lipid peroxidation and inflammation, and the level of plasma n-3 FA after intake of oxidised fish oil. In a double-blinded randomised controlled study, healthy subjects (aged 18–50 years, n 54) were assigned into one of three groups receiving capsules containing either 8 g/d of fish oil (1·6 g/d EPA+DHA; n 17), 8 g/d of oxidised fish oil (1·6 g/d EPA+DHA; n 18) or 8 g/d of high-oleic sunflower oil (n 19). Fasting blood and morning spot urine samples were collected at weeks 0, 3 and 7. No significant changes between the different groups were observed with regard to urinary 8-iso-PGF2α; plasma levels of 4-hydroxy-2-hexenal, 4-hydroxy-2-nonenal and α-tocopherol; serum high sensitive C-reactive protein; or activity of antioxidant enzymes in erythrocytes. A significant increase in plasma level of EPA+DHA was observed in both fish oil groups, but no significant difference was observed between the fish oil groups. No changes in a variety of in vivo markers of oxidative stress, lipid peroxidation or inflammation were observed after daily intake of oxidised fish oil for 3 or 7 weeks, indicating that intake of oxidised fish oil may not have unfavourable short-term effects in healthy human subjects. |
| Databáze: | OpenAIRE |
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