Corrigendum: There Is (Scientific) Strength in Numbers: A Comprehensive Quantitation of Fc Gamma Receptor Numbers on Human and Murine Peripheral Blood Leukocytes
| Autor: | Christina Kerntke, Falk Nimmerjahn, Markus Biburger |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Blood Platelets
Male murine leukocytes Immunology receptor numbers Mice neutrophils ddc:570 Leukocytes Animals Humans antibodies Immunology and Allergy human leukocytes Original Research Mice Knockout B-Lymphocytes Fc receptors Receptors IgG Correction RC581-607 Naturwissenschaftliche Fakultät Healthy Volunteers quantification Basophils Eosinophils Killer Cells Natural Mice Inbred C57BL Haplotypes Immunoglobulin G Leukocytes Mononuclear Female Immunologic diseases. Allergy monocytes |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 12 (2022) |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2021.840026 |
| Popis: | Antibodies are essential mediators of immunological defense mechanisms, are clinically used as therapeutic agents, but are also functionally involved in various immune-mediated disorders. Whereas IgG antibodies accomplish some of their biological tasks autonomously, many functions depend on their binding to activating and inhibitory Fcγ receptors (FcγR). From a qualitative point of view expression patterns of FcγR on immunologically relevant cell types are well-characterized both for mice and humans. Surprisingly, however, there is only quite limited information available on actual quantities of FcγR expressed by the different leukocyte populations. In this study we provide a comprehensive data set assessing quantitatively how many individual human and mouse FcγRs are expressed on B cells, NK cells, eosinophils, neutrophils, basophils and both classical, and non-classical monocytes under steady state conditions. Moreover, among human donors we found two groups with different expression levels of the inhibitory FcγRIIb on monocytes which appears to correlate with haplotypes of the activating FcγRIIIa. |
| Databáze: | OpenAIRE |
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