Antibody response to Schistosoma haematobium and other helminth species in malaria-exposed populations from Burkina Faso

Autor: David Modiano, Mireille Ouedraogo, Youssouf Kaboré, Claretta Bianchi, Fabrizio Bruschi, Valentina D. Mangano, Patrick H. Corran, Nilupa Silva, Issa Nebie, Sodiomon B. Sirima
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
medicine.disease_cause
fulani
immunity
lymphatic filariasis
malaria
schistosomiasis
soil-transmitted helminths
sub-saharan africa
0302 clinical medicine
Malaria
Falciparum
Child
Lymphatic filariasis
Schistosoma haematobium
education.field_of_study
biology
Middle Aged
030108 mycology & parasitology
Infectious Diseases
Wuchereria bancrofti
Child
Preschool
Female
Falciparum
Adult
Adolescent
Veterinary (miscellaneous)
030231 tropical medicine
Population
Antibodies
Helminth
Fulani
Immunity
Malaria
Schistosomiasis
Soil-transmitted helminths
Sub-Saharan Africa
Animals
Burkina Faso
Humans
Immunoglobulin G
Infant
Infant
Newborn
Young Adult
Antibodies
Strongyloides stercoralis
03 medical and health sciences
parasitic diseases
Helminth
medicine
Helminths
Preschool
education
Plasmodium falciparum
Newborn
medicine.disease
biology.organism_classification
Insect Science
Immunology
Parasitology
Popis: Infection with helminths in sub-Saharan Africa could modulate the immune response towards Plasmodium falciparum as well as susceptibility to malaria infection and disease. The aim of this study is to assess the antibody responses to helminths species in malaria-exposed populations from Burkina Faso. Plasma samples were collected in rural villages inhabited by Fulani, Mossi and Rimaibe communities, and IgG against parasitic helminths were measured by ELISA. The prevalence of IgG against antigens of Strongyloides stercoralis, Wuchereria bancrofti and Schistosoma haematobium (Soluble Egg Antigen, SEA) was 5%, 16% and 63% respectively, in line with estimates of infection prevalence in the region for the three parasites. Anti-SEA IgG prevalence was highest at 10–20 years of age, higher in males than females, and did not show differences between ethnic groups. However, the Fulani showed lower levels of anti-SEA IgG suggesting that lighter S. haematobium infections may occur in the ethnic group known for a marked lower susceptibility to P. falciparum. The present data support the use of serological methods for integrated surveillance of neglected tropical diseases such as soil-transmitted helminths, lymphatic filariasis and bilharzia. Furthermore, as helminth infections might promote downregulation of immune responses against intracellular pathogens, the observation of lower anti-SEA IgG levels in the malaria resistant Fulani population warrants further investigation into the immunological cross-talk between S. haematobium and P. falciparum in this geographical region.
Databáze: OpenAIRE
Externí odkaz: