Hypercalcemia is associated with a poor prognosis in lymphoma a retrospective monocentric matched-control study and extensive review of published reported cases

Autor: Amélie Foucault, Philippe Colombat, Nicolas Vallet, Alban Villate, Olivier Herault, Emmanuel Gyan, Chantal Barin-Le Guellec, Marjan Ertault, Thomas Chalopin, Julien Lejeune, Martin Eloit, Jean-Baptiste Delaye, Laurianne Drieu La Rochelle
Rok vydání: 2020
Předmět:
Zdroj: Annals of Hematology. 99:229-239
ISSN: 1432-0584
0939-5555
DOI: 10.1007/s00277-019-03890-w
Popis: The prognostic significance of hypercalcemia in lymphoma has only been studied on small series to date. We conducted a retrospective, monocentric, matched-control study that aimed to compare the outcome of patients diagnosed with any histological subtype of lymphoma associated with hypercalcemia, at diagnosis or relapse, with a group of controls matched for histological and prognostic factors. Sixty-two and 118 comparable patients treated between 2000 and 2016 were included in hypercalcemia and control cohorts, respectively. Hypercalcemia was found mainly at diagnosis (71%) in higher-risk patients (prognosis scores ≥ 3, 76%) and those with diffuse large B cell lymphoma (67.7%), stage III/IV disease (91.9%), and elevated LDH (90.3%). Two-year progression-free survival (PFS) was shorter in the hypercalcemia than control cohort [30.1% (95% confidence interval (95% CI) 18.3–41.9) vs 63.9% (95% CI 5.1–72.7), p
Databáze: OpenAIRE
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