Achievement of the low-density lipoprotein cholesterol goal among patients with dyslipidemia in South Korea
| Autor: | Siin Kim, Pratik P. Rane, Yi Qian, Sola Han, Hae Sun Suh, Zhongyun Zhao |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Health Screening Epidemiology 030204 cardiovascular system & hematology Overweight Logistic regression Vascular Medicine Biochemistry 0302 clinical medicine Medicine and Health Sciences Coronary Heart Disease Public and Occupational Health 030212 general & internal medicine Sex Characteristics Multidisciplinary Age Factors Drugs Middle Aged Lipids Cholesterol Cardiovascular Diseases Cohort Medicine Female medicine.symptom Research Article Acute coronary syndrome medicine.medical_specialty Statin medicine.drug_class Science Lipoproteins Cardiology Medication Adherence 03 medical and health sciences Internal medicine Republic of Korea medicine Humans Aged Dyslipidemias Retrospective Studies Pharmacology business.industry Statins Biology and Life Sciences Proteins Retrospective cohort study Cholesterol LDL medicine.disease Logistic Models Dyslipidemia Metabolic Disorders Medical Risk Factors Hydroxymethylglutaryl-CoA Reductase Inhibitors business Body mass index |
| Zdroj: | PLoS ONE PLoS ONE, Vol 15, Iss 1, p e0228472 (2020) |
| ISSN: | 1932-6203 |
| Popis: | Background It is important to achieve the low-density lipoprotein cholesterol (LDL-C) goal recommended by clinical guidelines in managing the risk of cardiovascular (CV) events, however, the current management of LDL-C in actual clinical settings is suboptimal. We examined the LDL-C level among patients with dyslipidemia against the 2015 Korean guidelines, the crude rates of CV events based on LDL-C goal achievement, and the factors associated with LDL-C goal achievement. Methods This was a retrospective cohort study using the National Health Insurance Service–National Health Screening Cohort (NHIS-HEALS) database from 2006 to 2013. Patients who had a health examination with LDL-C measurement between January 1, 2007, and December 31, 2011 were identified. Patients were required to have at least one diagnosis of dyslipidemia during the 1 year before the index date, defined as the first date of LDL-C measurement. The 2015 Korean guidelines were used to measure LDL-C goal achievement based on the CV risk level. Crude CV event rates were calculated for total and individual CV events as the number of events divided by person-years (PYs) during the follow-up period. CV events included acute coronary syndrome, ischemic stroke, peripheral artery disease, CV death, and all-cause death. Factors associated with LDL-C goal achievement were assessed using logistic regression. Results In the NHIS-HEALS database, 69,942 patients met the eligibility criteria: 36.7%, 22.5%, 20.1%, and 20.6% were among the very high-, high-, moderate-, and low-risk groups for the CV events, respectively, as defined by the 2015 Korean guidelines. Approximately half of the patients with dyslipidemia (47.6%) achieved their recommended LDL-C goal, but the achievement rates were substantially different across CV risk levels (17.6%, 47.2%, 66.9%, and 82.4% for very high-, high-, moderate-, and low-risk groups, respectively; P |
| Databáze: | OpenAIRE |
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