Desmoid-type fibromatosis: Tumour response assessment using magnetic resonance imaging signal and size criteria
| Autor: | Ying-Shi Sun, Hui-Ci Zhu, Xiao-Ting Li, Wan-Ying Ji, Shu Li |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Fibromatosis Magnetic resonance imaging Retrospective cohort study Desmoid type fibromatosis medicine.disease Tumour response Signal Magnetic Resonance Imaging 030218 nuclear medicine & medical imaging 03 medical and health sciences Fibromatosis Aggressive 0302 clinical medicine Stable Disease 030220 oncology & carcinogenesis Aggressive fibromatosis medicine Humans Radiology Nuclear Medicine and imaging Radiology business Follow-Up Studies Retrospective Studies |
| Zdroj: | Clinical imaging. 68 |
| ISSN: | 1873-4499 |
| Popis: | This study aimed to establish a specified magnetic resonance imaging (MRI) signal and size criterion for assessing the response of desmoid-type fibromatosis (DF).This retrospective study included 129 patients with DF who received non-surgical therapy. All patients underwent pretreatment and 6-month-interval follow-up MRI for3 years (6 follow-up visits). The correlation between signal grade and size was determined. Signal grade and size among three response groups (partial response [PR], stable disease [SD], progression disease [PD]) were compared. The specified signal and size criterion was established, used to assess tumour response at each follow-up, and compared with the reference. The Response Evaluation Criteria in Solid Tumours (RECIST)1.1 criterion at the end of the 3rd year was considered the reference.MRI signals were moderately correlated with size changes (r = -0.56 and -0.41 for T2 grade and contrast-enhanced T1 grade, respectively). Changes in T2 grade and size in the three response groups were significantly different (all p 0.01). The signal and size criterion accurately predicted 95% of PR patients at 2nd follow-up and 81.2% of PD patients at the 3rd follow-up, while only 13.1% of PR and 56.3% of PD patients were predicted by RECIST1.1. However, the accuracy of the signalsize criterion for predicting SD was lower than that of RECIST1.1.MRI signal is useful in assessing the response of DF. Signalsize criterion can identify patients with PR and PD earlier than RECIST1.1. |
| Databáze: | OpenAIRE |
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