Antibody-dependent cellular cytotoxicity and neutralization of human immunodeficiency virus type 1 by high affinity cross-linking of gp41 to human macrophage Fc IgG receptor using bispecific antibody
| Autor: | Aloïse Mabondzo, Bruno Vaslin, J. Bartholeyns, Hervé Raoul, R. Le Naour, J.-L. Romet-Lemonne, Dominique Dormont, F. Boussin, G. Gras |
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| Rok vydání: | 1994 |
| Předmět: |
Cellular immunity
medicine.drug_class HIV Infections In Vitro Techniques Monoclonal antibody Gp41 Virus Neutralization Cell Line Proviruses Neutralization Tests Virology Antibodies Bispecific medicine Humans Receptor Antibody-dependent cell-mediated cytotoxicity biology Macrophages Receptors IgG Antibody-Dependent Cell Cytotoxicity Molecular biology HIV Envelope Protein gp41 DNA Viral HIV-1 biology.protein Immunotherapy Antibody |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1465-2099 0022-1317 |
| DOI: | 10.1099/0022-1317-75-6-1451 |
| Popis: | Human monocytes/macrophages, which express Fc receptors for IgG are involved in human immunodeficiency virus type 1 (HIV-1) infection and pathogenesis. These receptors are known to mediate numerous immunological functions including cell-mediated killing and possibly targeting of HIV to the lysophagosome monocyte-derived macrophage (MDM) entry route for virus neutralization. To study both activities in HIV-1 infection, MDM Fc gamma RI was specifically selected using bispecific antibody (Bs-Ab) containing whole human monoclonal antibody against gp41 and the Fab' fragment of murine anti-Fc gamma RI 22.2 antibody. Bs-Ab was found to mediate potent antibody-dependent cellular cytotoxicity and virus neutralization. |
| Databáze: | OpenAIRE |
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