Cytokine gene polymorphism among Indigenous Australians
| Autor: | Rodney J. Scott, C. Caroline Blackwell, Amanda J. Cox, Sophia M. Moscovis |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Native Hawaiian or Other Pacific Islander Genotype Immunology Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide Microbiology White People Indigenous symbols.namesake Gene Frequency Population Groups Polymorphism (computer science) Genetic variation Humans International HapMap Project Molecular Biology Inflammation Sanger sequencing Genetics Australia Cell Biology Genotype frequency SNP genotyping Infectious Diseases symbols Cytokines Risk Reduction Behavior |
| Zdroj: | Innate Immunity. 20:431-439 |
| ISSN: | 1753-4267 1753-4259 |
| DOI: | 10.1177/1753425913498911 |
| Popis: | The health profile of Indigenous Australians is characterised by high rates of classic ‘lifestyle’ diseases. Potential roles of inflammation in pathophysiology of these diseases requires investigation. It is not clear if genetic regulation of inflammation in Indigenous Australians is similar to other populations. This study characterised frequencies of single nucleotide polymorphisms (SNPs) for eight cytokine genes for 100 individuals from a remote Indigenous Australian community and assessed novel genetic variants in four cytokine genes. We used a commercially-available allelic discrimination assay for SNP genotyping; re-sequencing was undertaken by standard Sanger sequencing methodologies for 26 samples. Frequencies of cytokine gene SNPs differed significantly from the Caucasian population ( P |
| Databáze: | OpenAIRE |
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