Favorable lifestyle before diagnosis associated with lower risk of screen-detected advanced colorectal neoplasia
| Autor: | Anette Hjartåker, Tomm Bernklev, Chloé B. Steen, Dung Hong Nguyen, Markus Dines Knudsen, Geir Hoff, Thomas de Lange, Paula Berstad, Edoardo Botteri, Helge Evensen |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Alcohol Drinking Health Behavior Observational Study Overweight Lower risk Body Mass Index 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Surveys and Questionnaires Carcinoma Odds Ratio Medicine Humans Healthy Lifestyle Exercise Life Style Sigmoidoscopy Early Detection of Cancer Aged Gynecology Screen detected medicine.diagnostic_test business.industry Norway Smoking Gastroenterology General Medicine Odds ratio Middle Aged medicine.disease digestive system diseases Logistic Models 030220 oncology & carcinogenesis Occult Blood 030211 gastroenterology & hepatology Female medicine.symptom Health behavior Diet Healthy business Colorectal Neoplasms Body mass index |
| Popis: | To investigate the association between adherence to health recommendations and detection of advanced colorectal neoplasia (ACN) in colorectal cancer (CRC) screening.A total of 14832 women and men were invited to CRC screening, 6959 in the fecal immunochemical test arm and 7873 in the flexible sigmoidoscopy arm. These were also sent a self-reported lifestyle questionnaire to be completed prior to their first CRC screening. A lifestyle score was created to reflect current adherence to healthy behaviors in regard to smoking, body mass index, physical activity, alcohol consumption and food consumption, and ranged from zero (poorest) to six (best). Odds ratios (ORs) and 95%CIs were calculated using multivariable logistic regression to evaluate the association between the single lifestyle variables and the lifestyle score and the probability of detecting ACN.In all 6315 women and men completed the lifestyle questionnaire, 3323 (53%) in the FIT arm and 2992 (47%) in the FS arm. This was 89% of those who participated in screening. ACN was diagnosed in 311 (5%) participants of which 25 (8%) were diagnosed with CRC. For individuals with a lifestyle score of two, three, four, and five-six, the ORs (95%CI) for the probability of ACN detection were 0.82 (0.45-1.16), 0.43 (0.28-0.73), 0.41 (0.23-0.64), and 0.41 (0.22-0.73), respectively compared to individuals with a lifestyle score of zero-one. Of the single lifestyle factors, adherence to non-smoking and moderate alcohol intake were associated with a decreased probability of ACN detection compared to being a smoker or having a high alcohol intake 0.53 (0.42-0.68) and 0.63 (0.43-0.93) respectively.Adopted healthy behaviors were inversely associated with the probability of ACN detection. Lifestyle assessment might be useful for risk stratification in CRC screening. |
| Databáze: | OpenAIRE |
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