Scarless excision of an insertion sequence restores capsule production and virulence in Acinetobacter baumannii

Autor: Clémence Whiteway, Adam Valcek, Chantal Philippe, Mojca Strazisar, Tim De Pooter, Ivan Mateus, Anke Breine, Charles Van der Henst
Přispěvatelé: Faculty of Sciences and Bioengineering Sciences, Department of Bio-engineering Sciences
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: The ISME journal : multidisciplinary journal of microbial ecology
Whiteway, C, Valcek, A, Philippe, C, Strazisar, M, De Pooter, T, Mateus, I, Breine, A & Van der Henst, C 2022, ' Scarless excision of an insertion sequence restores capsule production and virulence in Acinetobacter baumannii ', ISME Journal, vol. 16, no. 5, pp. 1473-1477 . https://doi.org/10.1038/s41396-021-01179-3
ISSN: 1751-7370
1751-7362
Popis: We identify a new mechanism mediating capsule production and virulence in the WHO and CDC priority ESKAPE pathogen Acinetobacter baumannii. Non-capsulated and avirulent bacteria can revert into a capsulated and virulent state upon scarless excision of an ISAba13 insertion sequence under stress conditions. Reversion events fully restore capsule production and in vivo virulence. This increases our knowledge about A. baumannii genome dynamics, and the regulation of capsule production, virulence and resistance.
Databáze: OpenAIRE
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