Sound Out the Deep Colors: Photoacoustic Molecular Imaging at New Depths
| Autor: | Junjie Yao, Jonathan F. Lovell, Mucong Li, Hailey I Kilian, Nikhila Nyayapathi, Jun Xia |
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| Rok vydání: | 2020 |
| Předmět: |
Biomedical Engineering
Color Image processing 02 engineering and technology Iterative reconstruction photoacoustic tomography 01 natural sciences Photoacoustic Techniques 010309 optics Optics 0103 physical sciences Image Processing Computer-Assisted image reconstruction methods Radiology Nuclear Medicine and imaging Penetration depth Review Articles Physics Wavefront business.industry Attenuation optical fluence compensation penetration depth molecular imaging 021001 nanoscience & nanotechnology Condensed Matter Physics near-infrared molecular probes Molecular Medicine Ultrasonic sensor Molecular imaging Tomography X-Ray Computed 0210 nano-technology business Focus (optics) Biotechnology |
| Zdroj: | Molecular Imaging |
| ISSN: | 1536-0121 |
| DOI: | 10.1177/1536012120981518 |
| Popis: | Photoacoustic tomography (PAT) has become increasingly popular for molecular imaging due to its unique optical absorption contrast, high spatial resolution, deep imaging depth, and high imaging speed. Yet, the strong optical attenuation of biological tissues has traditionally prevented PAT from penetrating more than a few centimeters and limited its application for studying deeply seated targets. A variety of PAT technologies have been developed to extend the imaging depth, including employing deep-penetrating microwaves and X-ray photons as excitation sources, delivering the light to the inside of the organ, reshaping the light wavefront to better focus into scattering medium, as well as improving the sensitivity of ultrasonic transducers. At the same time, novel optical fluence mapping algorithms and image reconstruction methods have been developed to improve the quantitative accuracy of PAT, which is crucial to recover weak molecular signals at larger depths. The development of highly-absorbing near-infrared PA molecular probes has also flourished to provide high sensitivity and specificity in studying cellular processes. This review aims to introduce the recent developments in deep PA molecular imaging, including novel imaging systems, image processing methods and molecular probes, as well as their representative biomedical applications. Existing challenges and future directions are also discussed. |
| Databáze: | OpenAIRE |
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