Flower Forms an Extracellular Code that Reveals the Fitness of a Cell to its Neighbors in Drosophila
| Autor: | Jesús M. López-Gay, Sergio Casas-Tintó, Eduardo Moreno, Luis Lombardía, Davide Soldini, Christa Rhiner, Francisco A. Martín |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Cell Survival
Organogenesis Cell Population DEVBIO Apoptosis Cell Communication General Biochemistry Genetics and Molecular Biology Cell membrane 03 medical and health sciences 0302 clinical medicine Drosophilidae Botany medicine Extracellular Animals Drosophila Proteins Protein Isoforms Wings Animal education Molecular Biology 030304 developmental biology Regulation of gene expression 0303 health sciences education.field_of_study biology Cell Membrane Gene Expression Regulation Developmental Cell Differentiation Cell Biology biology.organism_classification Up-Regulation Cell biology Imaginal disc Drosophila melanogaster medicine.anatomical_structure SIGNALING 030220 oncology & carcinogenesis CELLBIO Calcium Channels Extracellular Space Developmental Biology |
| Zdroj: | Developmental Cell. 18:985-998 |
| ISSN: | 1534-5807 |
| DOI: | 10.1016/j.devcel.2010.05.010 |
| Popis: | Cell competition promotes the elimination of weaker cells from a growing population. Here we investigate how cells of Drosophila wing imaginal discs distinguish "winners" from "losers" during cell competition. Using genomic and functional assays, we have identified several factors implicated in the process, including Flower (Fwe), a cell membrane protein conserved in multicellular animals. Our results suggest that Fwe is a component of the cell competition response that is required and sufficient to label cells as "winners" or "losers." In Drosophila, the fwe locus produces three isoforms, fwe(ubi), fwe(Lose-A), and fwe(Lose-B). Basal levels of fwe(ubi) are constantly produced. During competition, the fwe(Lose) isoforms are upregulated in prospective loser cells. Cell-cell comparison of relative fwe(Lose) and fwe(ubi) levels ultimately determines which cell undergoes apoptosis. This "extracellular code" may constitute an ancient mechanism to terminate competitive conflicts among cells. |
| Databáze: | OpenAIRE |
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