Relation of white matter hyperintensities and motor deficits in chronic stroke

Autor:	Edward Taub, Brent Womble, Gitendra Uswatte, Victor W. Mark, Jarrod M Hicks, Ameen Barghi, Tyler Rickards
Rok vydání:	2018
Předmět:	Adult Male medicine.medical_specialty Movement disorders Pyramidal Tracts 050105 experimental psychology Upper Extremity 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Developmental Neuroscience Centrum semiovale medicine Humans 0501 psychology and cognitive sciences Stroke Aged Aged 80 and over Movement Disorders Pyramidal tracts business.industry 05 social sciences Recovery of Function Middle Aged medicine.disease Magnetic Resonance Imaging White Matter Hyperintensity Hemiparesis medicine.anatomical_structure Neurology Chronic Disease Corticospinal tract Female Neurology (clinical) medicine.symptom business Motor Deficit 030217 neurology & neurosurgery
Zdroj:	Restorative Neurology and Neuroscience. 36:349-357
ISSN:	1878-3627 0922-6028
Popis:	Background Infarct size and location account for only a relatively small portion of post-stroke motor impairment, suggesting that other less obvious factors may be involved. Objective Examine the relationship between white matter hyperintensity (WMH) load among other factors and upper extremity motor deficit in patients with mild to moderate chronic stroke. Methods The magnetic resonance images of 28 patients were studied. WMH load was assessed as total WMH volume and WMH overlap with the corticospinal tract in the centrum semiovale. Hemiparetic arm function was measured using the Motor Activity Log (MAL) and Wolf Motor Function Test (WMFT). Results Hierarchical multiple regression models found WMH volume predicted motor deficits in both real-world arm use (MAL;ΔR2 = 0.12, F(1, 22) = 4.73, p = 0.04) and in arm motor capacity as measured by a laboratory motor function test (WMFT;ΔR2 = 0.18, F(1, 22) = 6.32, p = 0.02) over and above age and lesion characteristics. However, these models accounted for less than half of the variance in post-stroke motor deficits. Conclusion The results suggest that WMH may be an important factor to consider in stroke-related upper extremity motor impairment. Nonetheless, the basis of the largest part of the post-stroke motor deficit remains unaccounted for by structural CNS factors. This component may be behavioral or learned, involving learned nonuse.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c17945b9d7287f2b046769c7b80035 https://doi.org/10.3233/rnn-170746 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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