The neuroprotective effect of Riparin IV on oxidative stress and neuroinflammation related to chronic stress-induced cognitive impairment
| Autor: | Daniel Moreira Alves da Silva, Alyne Mara Rodrigues de Carvalho, Auriana Serra Vasconcelos Mallmann, Victor Celso Cavalcanti Capibaribe, Stanley Juan Chavez Gutierrez, Francisca Cléa Florenço de Sousa, Iardja Stéfane Lopes, Raquell de Castro Chaves, Marta Maria de França Fonteles, José Maria Barbosa Filho, Giovanna Riello Barbosa, José Tiago Valentim, Natália Ferreira de Oliveira |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
endocrine system Tyramine Fluvoxamine Pharmacology medicine.disease_cause Neuroprotection Antioxidants Mice 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound 0302 clinical medicine Endocrinology Corticosterone medicine Animals Cognitive Dysfunction Chronic stress Cognitive deficit Behavior Animal Depression Endocrine and Autonomic Systems business.industry Brain medicine.disease 030227 psychiatry Oxidative Stress Neuroprotective Agents chemistry Chronic Disease Encephalitis Antidepressant Major depressive disorder Female medicine.symptom business Stress Psychological hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery Oxidative stress medicine.drug |
| Zdroj: | Hormones and Behavior. 122:104758 |
| ISSN: | 0018-506X |
| DOI: | 10.1016/j.yhbeh.2020.104758 |
| Popis: | Background Cognitive impairment is identified as one of the diagnostic criteria for major depressive disorder and can extensively affect the quality of life of patients. Based on these findings, this study aimed to investigate the possible effects of Riparin IV (Rip IV) on cognitive impairment induced by chronic administration of corticosterone in mice. Methods Female Swiss mice were divided into four groups: control (Control), corticosterone (Cort), Riparin IV (Cort + Rip IV), and Fluvoxamine (Cort + Flu). Three groups were administered corticosterone (20 mg/kg) subcutaneously during the 22-day study, while the control group received only vehicle. After the 14th day, the groups were administered medications: Riparin IV (Rip IV), fluvoxamine (Flu), or distilled water, by gavage, 1 h after the subcutaneous injections. After treatment, mice underwent behavioral testing, and brain areas were removed for oxidative stress and cytokine content assays. Results The results revealed that Cort-treated mice developed a cognitive impairment and exhibited a neuroinflammatory profile with an oxidative load and Th1/Th2 cytokine imbalance. Rip IV treatment significantly ameliorated the cognitive deficit induced by Cort and displayed a neuroprotective effect. Conclusion The antidepressant-like ability of Rip IV treatment against chronic Cort-induced stress may be due to its potential to mitigate inflammatory damage and oxidative stress. The antioxidant and anti-inflammatory effect observed indicates Rip IV as a possible drug for antidepressant treatment of non-responsive patients with severe and cognitive symptoms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect