Sepiolite Clay Attenuates the Development of Hypercholesterolemia and Obesity in Mice Fed a High-Fat High-Cholesterol Diet
| Autor: | Adi Jonas-Levi, Giora Rytwo, Yelena Konovalova, Annat Neuman, Maayan Rauch, Roee Gutman, Hazem Khamaisi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Hypercholesterolemia Medicine (miscellaneous) Absorption (skin) Diet High-Fat Weight Gain Intestinal absorption Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Magnesium Silicates High cholesterol diet Hyperlipidemia medicine Animals Humans Obesity Food science Triglycerides 030109 nutrition & dietetics Nutrition and Dietetics Cholesterol Sepiolite nutritional and metabolic diseases medicine.disease Mice Inbred C57BL chemistry 030220 oncology & carcinogenesis Clay lipids (amino acids peptides and proteins) Metabolic syndrome |
| Zdroj: | Journal of Medicinal Food. 23:289-296 |
| ISSN: | 1557-7600 1096-620X |
| DOI: | 10.1089/jmf.2019.0030 |
| Popis: | Obesity reduces the quality of life and life expectancy, whereas nonoperative interventions have shown poor results so far. Statins effectively combat hypercholesterolemia but are not well tolerated at high doses, raising the need for coprescription with cholesterol sorbents and/or absorption inhibitors. Montmorillonite (MMT) clay was found to attenuate hypercholesterolemia and obesity by reducing cholesterol and fat absorption. However, acicular clay-like sepiolite may offer better results due to its more substantial adsorption of nonpolar molecules. We herein aimed at (1) assessing in vitro the capacity of sepiolite to adsorb edible oil and cholesterol compared with that of MMT and (2) assessing in vivo the effect of continuous feeding on a high-fat high-cholesterol diet (HFD) (53.6% w/w fat and 0.2% cholesterol) supplemented with 5% (w/w) edible sepiolite, on diet-induced obesity rate, hypercholesterolemia, and hyperlipidemia. Fourier transform infrared spectroscopy showed in vitro that sepiolite adsorption of olive oil and cholesterol was five to eight times greater than that of MMT clay. Sepiolite supplementation to HFD fed to mature mice for 12.5 weeks resulted in lower total blood cholesterol and triacylglycerol levels and attenuated body weight gain, by reducing fat gain. Sepiolite supplementation did not affect energy intake but increased fecal extraction of sterols and lipids, without notable side effects. These results demonstrate that supplementing a HFD with sepiolite attenuates gastrointestinal absorption of dietary lipids and sterols, thus mitigating obesity, hyperlipidemia, and hypercholesterolemia. Further exploration of the efficacy, mechanism of action, and safety of sepiolite as a food supplement for combating the metabolic syndrome is needed. |
| Databáze: | OpenAIRE |
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