CR2Cancer: a database for chromatin regulators in human cancer
| Autor: | Aditi Chandra, Jianlong Sun, Wai Lam Wun, Zarina Levitskaya, Larry Ka-Yue Chow, Acacia Tsz So Tang, CN Wong, Yin Tong, Beibei Ru, Jiangwen Zhang |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Databases Factual Gene Dosage Information Storage and Retrieval Biology medicine.disease_cause computer.software_genre Genome Chromatin remodeling Epigenesis Genetic Substrate Specificity Transcriptome User-Computer Interface 03 medical and health sciences Protein Domains Neoplasms Databases Genetic Genetics medicine Database Issue Data Mining Humans RNA Neoplasm Cancer epigenetics Databases Protein Epigenomics Mutation Database Data Collection Cancer Molecular Sequence Annotation DNA Methylation Chromatin Assembly and Disassembly medicine.disease Enzymes High-Throughput Screening Assays Chromatin Gene Expression Regulation Neoplastic Histone Code 030104 developmental biology computer Forecasting |
| Zdroj: | Nucleic Acids Research |
| ISSN: | 1362-4962 0305-1048 |
| DOI: | 10.1093/nar/gkx877 |
| Popis: | Chromatin regulators (CRs) can dynamically modulate chromatin architecture to epigenetically regulate gene expression in response to intrinsic and extrinsic signalling cues. Somatic alterations or misexpression of CRs might reprogram the epigenomic landscape of chromatin, which in turn lead to a wide range of common diseases, notably cancer. Here, we present CR2Cancer, a comprehensive annotation and visualization database for CRs in human cancer constructed by high throughput data analysis and literature mining. We collected and integrated genomic, transcriptomic, proteomic, clinical and functional information for over 400 CRs across multiple cancer types. We also built diverse types of CR-associated relations, including cancer type dependent (CR-target and miRNA-CR) and independent (protein-protein interaction and drug-target) ones. Furthermore, we manually curated around 6000 items of aberrant molecular alterations and interactions of CRs in cancer development from 5007 publications. CR2Cancer provides a user-friendly web interface to conveniently browse, search and download data of interest. We believe that this database would become a valuable resource for cancer epigenetics investigation and potential clinical application. CR2Cancer is freely available at http://cis.hku.hk/CR2Cancer. |
| Databáze: | OpenAIRE |
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