Effects of palmatine on BDNF/TrkB-mediated trigeminal neuralgia
| Autor: | Mengyun Sun, Yun Gao, Shujuan Li, Huixiang Ge, Cancan Yin, Wei Xiong, Lingkun He, Lijuan Liu, Wenhao Shen, Ruoyu Huang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Pain Threshold medicine.medical_specialty MAP Kinase Signaling System Berberine Alkaloids Gene Expression lcsh:Medicine Tropomyosin receptor kinase B Neuropathic pain Article Rats Sprague-Dawley Trigeminal ganglion chemistry.chemical_compound Neurotrophic factors Trigeminal neuralgia Internal medicine Medicine Animals Receptor trkB Phosphorylation lcsh:Science Trigeminal nerve Multidisciplinary business.industry Kinase Brain-Derived Neurotrophic Factor lcsh:R Chronic pain Palmatine Trigeminal Neuralgia medicine.disease Immunohistochemistry Disease Models Animal Endocrinology chemistry Trigeminal Ganglion nervous system lcsh:Q business Somatic system Drugs Chinese Herbal Phytotherapy |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-61969-1 |
| Popis: | Trigeminal neuralgia (TN), a sudden, needle-like pain in the distribution area of the trigeminal nerve, can seriously affect the physical and mental health of patients. In chronic pain conditions including TN, increased levels of brain-derived neurotrophic factor (BDNF) may enhance pain transmission. This study compares the effect of palmatine administration on the expression of BDNF and its receptor TrkB (tropomyosin receptor kinase B) in trigeminal ganglion cells of Sprague-Dawley rats in a sham versus TN model group. Within 14 days of surgery, the mechanical allodynia threshold of the TN group was significantly lower than that of the sham group, while the TN + palmatine group had a higher mechanical pain sensitivity threshold than the TN group (p |
| Databáze: | OpenAIRE |
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