Comparative Assessment of the Accuracy of Cytological and Histologic Biopsies in the Diagnosis of Canine Bone Lesions

Autor: Andrea Renzi, Paolo Buracco, Ombretta Capitani, S. Defourny, M. Garnier-Moiroux, Silvia Sabattini, Giuliano Bettini
Přispěvatelé: Sabattini, S., Renzi, A., Buracco, P., Defourny, S., Garnier-Moiroux, M., Capitani, O., Bettini, G
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Pathology
medicine.medical_specialty
Histology
040301 veterinary sciences
medicine.medical_treatment
Fibrosarcoma
Biopsy
Fine-Needle
Chondrosarcoma
Bone Neoplasms
Disease
Standard Article
Sensitivity and Specificity
Bone and Bones
0403 veterinary science
Diagnosis
Differential
03 medical and health sciences
0302 clinical medicine
Dogs
Bone tumors
Cytology
Histology
Dog
Osteosarcoma
Cytology
Carcinoma
Bone tumors
Dog
Medicine
Animals
Dog Diseases
Bone tumor
Reduction (orthopedic surgery)
Retrospective Studies
Osteosarcoma
General Veterinary
business.industry
Reproducibility of Results
Retrospective cohort study
04 agricultural and veterinary sciences
medicine.disease
Standard Articles
Primary bone
Oncology
030220 oncology & carcinogenesis
Veterinary (all)
Female
SMALL ANIMAL
Bone Diseases
business
Zdroj: Journal of Veterinary Internal Medicine
ISSN: 1939-1676
0891-6640
Popis: Background Osteosarcoma (OSA) should be differentiated from other less frequent primary bone neoplasms, metastatic disease, and tumor-like lesions, as treatment and prognosis can vary accordingly. Hence, a preoperative histologic diagnosis is generally preferred. This requires collection of multiple biopsies under general anesthesia, with possible complications, including pathological fractures. Fine-needle aspiration cytology would allow an earlier diagnosis with a significant reduction of discomfort and morbidity. Hypothesis/Objectives The aim of this study was to compare the accuracy of cytological and histologic biopsies in the diagnosis of canine osteodestructive lesions. Animals Sixty-eight dogs with bone lesions. Methods Retrospective study. Accuracy was assessed by comparing the former diagnosis with the final histologic diagnosis on surgical or post-mortem samples or, in the case of non-neoplastic lesions, with follow-up information. Results The study included 50 primary malignant bone tumors (40 OSAs, 5 chondrosarcomas, 2 fibrosarcomas, and 3 poorly differentiated sarcomas), 6 carcinoma metastases, and 12 non-neoplastic lesions. Accuracy was 83% for cytology (sensitivity, 83.3%; specificity, 80%) and 82.1% for histology (sensitivity, 72.2%; specificity, 100%). Tumor type was correctly identified cytologically and histologically in 50 and 55.5% of cases, respectively. Conclusions and Clinical Importance The accuracy of cytology was similar to histology, even in the determination of tumor type. In no case was a benign lesion diagnosed as malignant on cytology. This is the most important error to prevent, as treatment for malignant bone tumors includes aggressive surgery. Being a reliable diagnostic method, cytology should be further considered to aid decisions in the preoperative setting of canine bone lesions.
Databáze: OpenAIRE
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