High-level pan-azole-resistant aspergillosis

Autor:	Paul E. Verweij, Antonius J. M. M. Rijs, Jakko van Ingen, Eveline Snelders, Henrich A. L. van der Lee, Willem J. G. Melchers
Jazyk:	angličtina
Rok vydání:	2015
Předmět:	Microbiology (medical) Antifungal Adult Azoles Male Antifungal Agents medicine.drug_class lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] Azole resistance Microbial Sensitivity Tests Mycology Gene mutation Aspergillosis Aspergillus fumigatus Microbiology Fungal Proteins Young Adult Cytochrome P-450 Enzyme System medicine Humans Life Science Aged chemistry.chemical_classification Fungal protein Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17] biology Middle Aged biology.organism_classification medicine.disease lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] chemistry Lung disease Immunology Mutation Azole Female Pulmonary Aspergillosis
Zdroj:	Journal of Clinical Microbiology, 53, 7, pp. 2343-5 Journal of Clinical Microbiology 53 (2015) 7 Journal of Clinical Microbiology, 53(7), 2343-2345 Journal of Clinical Microbiology, 53, 2343-5
ISSN:	0095-1137
DOI:	10.1128/jcm.00502-15
Popis:	High-level pan-azole-resistant Aspergillus fumigatus was recovered from four patients with chronic lung disease. In one patient, the development of progressive resistance followed long-term azole therapy and switching between antifungal azoles. The high-level pan-azole-resistant phenotypes were not associated with a specific cyp51A gene mutation. New strategies that avoid the development of progressive azole resistance are needed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5622643f3e241245e87c5bbce3fa067 https://doi.org/10.1128/jcm.00502-15 Zobrazit plný text záznamu