Dietary prevention of coronary heart disease in women: the Finnish mental hospital study
| Autor: | Erkki Paavilainen, Matti Miettinen, Maija Pekkarinen, Reino Elosuo, Martti J. Karvonen, Osmo Turpeinen |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Adult
medicine.medical_specialty Epidemiology Blood Pressure Coronary Disease 030204 cardiovascular system & hematology Cholesterol Dietary 03 medical and health sciences chemistry.chemical_compound Electrocardiography 0302 clinical medicine Internal medicine Statistical significance medicine Psychiatric hospital Humans 030212 general & internal medicine Aged medicine.diagnostic_test Cholesterol business.industry Incidence (epidemiology) Confounding Smoking Age Factors General Medicine Middle Aged 3. Good health Diet Clinical trial Blood pressure chemistry Adipose Tissue Cardiology Female business |
| Zdroj: | International journal of epidemiology. 12(1) |
| ISSN: | 0300-5771 |
| Popis: | A controlled intervention trial, with the purpose of testing the hypothesis that the incidence of coronary heart disease (CHD) could be decreased by the use of a serum-cholesterol-lowering (SCL) diet, was carried out in two mental hospitals near Helsinki in 1959-71. The subjects were hospitalized middle-aged women. One of the hospitals received the SCL diet, ie a diet low in saturated fats and cholesterol and relatively high in poly-unsaturated fats, while the other served as the control with a normal hospital diet. Six years later the diets were reversed, and the trial was continued another six years. The use of the SCL diet was associated with markedly lowered serum cholesterol values. The incidence of CHD, as measured by the appearance of certain electrocardiographic patterns and by the occurrence of coronary deaths, was in both hospitals during the SCL-diet periods lower than during the normal-diet periods. The differences, however, failed to reach statistical significance. An examination of a number of potential confounding variables indicated that the changes in them were small and failed to account for the reduction in the incidence of CHD. Although the results of this trial do not permit firm conclusions, they support the idea that also among female populations the SCL diet exerts a preventive effect on CHD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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