Bulky DNA Adducts in Cord Blood, Maternal Fruit-and-Vegetable Consumption, and Birth Weight in a European Mother–Child Study (NewGeneris)

Autor: Helle Margrete Meltzer, Leda Chatzi, Peter B. Farmer, Viktória Lukács, Laura J. Hardie, Nigel J. Brady, Jeanette K.S. Nielsen, Gunnar Brunborg, Hans von Stedingk, Margaretha Haugen, Roger W. L. Godschalk, Katalin Kovács, Kristine B. Gutzkow, Aina Espinosa, Marie Pedersen, Dan Segerbäck, Livia Anna, Silvia Agramunt, John Wright, Domenico Franco Merlo, Sarah Fleming, Maria Botsivali, Lisbeth E. Knudsen, Margareta Törnqvist, Bernadette Schoket, Eleni Fthenou, Jordi Sunyer, Manolis Kogevinas, Anette Landström, Jos C. S. Kleinjans, Jan Alexander, Khelifa Arab, Soterios A. Kyrtopoulos, Michelle A. Mendez
Přispěvatelé: RS: NUTRIM - R4 - Gene-environment interaction, Farmacologie en Toxicologie, Toxicogenomics, RS: GROW - School for Oncology and Reproduction
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Environmental Health Perspectives
Environmental Health Perspectives, 121(10), 1200-1206. U.S. Department of Health and Human Services; National Institute of Environmental Health Sciences
Recercat. Dipósit de la Recerca de Catalunya
instname
ISSN: 1552-9924
0091-6765
Popis: Background: Tobacco-smoke, airborne, and dietary exposures to polycyclic aromatic hydrocarbons (PAHs) have been associated with reduced prenatal growth. Evidence from biomarker-based studies of low-exposed populations is limited. Bulky DNA adducts in cord blood reflect the prenatal effective dose to several genotoxic agents including PAHs. Objectives: We estimated the association between bulky DNA adduct levels and birth weight in a multicenter study and examined modification of this association by maternal intake of fruits and vegetables during pregnancy. Methods: Pregnant women from Denmark, England, Greece, Norway, and Spain were recruited in 2006–2010. Adduct levels were measured by the 32P-postlabeling technique in white blood cells from 229 mothers and 612 newborns. Maternal diet was examined through questionnaires. Results: Adduct levels in maternal and cord blood samples were similar and positively correlated (median, 12.1 vs. 11.4 adducts in 108 nucleotides; Spearman rank correlation coefficient = 0.66, p < 0.001). Cord blood adduct levels were negatively associated with birth weight, with an estimated difference in mean birth weight of –129 g (95% CI: –233, –25 g) for infants in the highest versus lowest tertile of adducts. The negative association with birth weight was limited to births in Norway, Denmark, and England, the countries with the lowest adduct levels, and was more pronounced in births to mothers with low intake of fruits and vegetables (–248 g; 95% CI: –405, –92 g) compared with those with high intake (–58 g; 95% CI: –206, 90 g). Conclusions: Maternal exposure to genotoxic agents that induce the formation of bulky DNA adducts may affect intrauterine growth. Maternal fruit and vegetable consumption may be protective. The NewGeneris (Newborns and Genotoxic exposure risks) study was funded by the European Union (EU contract FOOD-CT-2005-016320). The study was also supported by the National Institute for Health Research, United Kingdom (programme grant RP-PG-0407-10044), the Norwegian Ministry of Health, the Norwegian Ministry of Education and Research, the Norwegian Research Council/FUGE (grant 151918/S10), the EU funded HiWATE (contract Food-CT-2006-036224), the U.S. National Institutes of Health (NIH)/National Institute of Environmental Health Sciences (contract NO-ES-75558), and the U.S. NIH/National Institute of Neurological Disorders and Stroke (grant 1 UO1 NS 047537-01). M.P. holds a Juan de la Cierva postdoctoral fellowship awarded from the Spanish Ministry of Science and Innovation (JCI-2011-09479) The NewGeneris (Newborns and Genotoxic exposure risks) study was funded by the European Union (EU contract FOOD-CT-2005-016320). The study/nwas also supported by the National Institute for Health Research, United Kingdom (programme grant RP-PG-0407-10044), the Norwegian Ministry of/nHealth, the Norwegian Ministry of Education and Research, the Norwegian Research Council/FUGE (grant 151918/S10), the EU funded HiWATE (contract Food-CT-2006-036224), the U.S. National Institutes of Health (NIH)/National Institute of Environmental Health Sciences (contract NO-ES-75558), and the U.S. NIH/National Institute of Neurological Disorders and Stroke (grant 1 UO1 NS 047537-01). M.P. holds a Juan de la Cierva postdoctoral fellowship awarded from the Spanish Ministry of Science and Innovation (JCI-2011-09479)
Databáze: OpenAIRE
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