Independent control of gamma and theta activity by distinct interneuron networks in the olfactory bulb
| Autor: | Andreas T. Schaefer, Jan T. Herb, Mihaly Kollo, Izumi Fukunaga, Edward S. Boyden |
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| Přispěvatelé: | Massachusetts Institute of Technology. Synthetic Neurobiology Group, Massachusetts Institute of Technology. Media Laboratory, Boyden, Edward Stuart |
| Rok vydání: | 2014 |
| Předmět: |
Patch-Clamp Techniques
Interneuron Neural Inhibition Mice Transgenic Biology Optogenetics Article Interneurons Lateral inhibition Gamma Rhythm medicine Animals Patch clamp Theta Rhythm Wakefulness Evoked Potentials musculoskeletal neural and ocular physiology General Neuroscience Olfactory Bulb Olfactory bulb Mice Inbred C57BL Smell medicine.anatomical_structure Odorants Neuroscience |
| Zdroj: | PMC Nature Neuroscience Nature neuroscience |
| ISSN: | 1546-1726 1097-6256 |
| DOI: | 10.1038/nn.3760 |
| Popis: | Circuits in the brain possess the ability to orchestrate activities on different timescales, but the manner in which distinct circuits interact to sculpt diverse rhythms remains unresolved. The olfactory bulb is a classic example of a place in which slow theta and fast gamma rhythms coexist. Furthermore, inhibitory interneurons that are generally implicated in rhythm generation are segregated into distinct layers, neatly separating local and global motifs. We combined intracellular recordings in vivo with circuit-specific optogenetic interference to examine the contribution of inhibition to rhythmic activity in the mouse olfactory bulb. We found that the two inhibitory circuits controlled rhythms on distinct timescales: local, glomerular networks coordinated theta activity, regulating baseline and odor-evoked inhibition, whereas granule cells orchestrated gamma synchrony and spike timing. Notably, granule cells did not contribute to baseline rhythms or sniff-coupled odor-evoked inhibition. Thus, activities on theta and gamma timescales are controlled by separate, dissociable inhibitory networks in the olfactory bulb. Deutsche Forschungsgemeinschaft (DFG-SPP1392) Max Planck Society for the Advancement of Science Alexander von Humboldt-Stiftung Germany. Federal Ministry of Education and Research (US-German collaboration computational neuroscience) Medical Research Council (Great Britain) (MC_UP_1202/5) University of Tubingen (ExcellenzCluster Cell Networks) |
| Databáze: | OpenAIRE |
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