Comparison of the Effects of Two Cholecystokinin-Receptor Antagonists, Loxiglumide and L-364,718, on the Pancreatic Secretory Response to Intraduodenal Tryptophan in Dogs
| Autor: | M. V. Singer, M. Hartel, Elke Niebergall-Roth, R. L. Riepl, D. Wetzel, Christoph Beglinger, Stephan Teyssen |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Duodenum Bicarbonate Devazepide Biology Cholecystokinin receptor Sincalide Secretin chemistry.chemical_compound Dogs Internal medicine medicine Animals Pancreas Cholecystokinin Benzodiazepinones Pancreatic Exocrine Secretion Tryptophan Gastroenterology Perfusion Bicarbonates Proglumide Endocrinology medicine.anatomical_structure chemistry Female Receptors Cholecystokinin |
| Zdroj: | Scandinavian Journal of Gastroenterology. 31:723-732 |
| ISSN: | 1502-7708 0036-5521 |
| DOI: | 10.3109/00365529609009157 |
| Popis: | The aim of the study was to compare the effects of the cholecystokinin (CCK)-receptor antagonists loxiglumide and L-364, 718 on the endogenously stimulated pancreatic exocrine secretion.In six conscious dogs with chronic gastric and pancreatic fistulas we compared the action of different doses of loxiglumide (2.5 to 10.0 mg/kg/h) and L-364, 718 (0.025 to 0.1 mg/kg/h) on the pancreatic secretory response to intraduodenal perfusion of graded loads of tryptophan (0.37-10.0 mmol/ h), given against a background of secretin (20.5 pmol/kg/h intravenously).Both loxiglumide and L-364, 718 inhibited the secretin-stimulated pancreatic bicarbonate output by up to 47% and 48%, respectively. The pancreatic protein output during secretin was significantly inhibited by all doses of L-364,718 (by 65% to 82%) but not by loxiglumide. All doses of loxiglumide and L-364, 718 abolished the 180-min integrated bicarbonate response to tryptophan. The two higher doses of loxiglumide (5.0-10.0 mg/kg/h) and L-364,718 (0.05-0.1 mg/kg/h) significantly decreased the 180-min integrated response to tryptophan by 59% and 79% (loxiglumide) and by 72% and 97% (L-364, 718). The plasma CCK-like immunoreactivity basally and in response to tryptophan was not significantly altered by loxiglumide or L-364, 718.These findings indicate that in dogs 1) the pancreatic bicarbonate response to secretin is augmented by the hormone CCK; 2) L-364, 718 but not loxiglumide decreases pancreatic protein output during secretin; 3) endogenous released CCK is involved in the pancreatic bicarbonate response and is a major mediator of pancreatic protein response to intraduodenal tryptophan; and 4) the release of CCK by intraduodenal tryptophan is not influenced by loxiglumide and L-364, 718. |
| Databáze: | OpenAIRE |
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