The effect of fentanyl on the end-tidal sevoflurane concentration needed to prevent motor movement in dogs
| Autor: | Christine M. Egger, Thomas J Doherty, Reza Seddighi, James R. Johnson, Sabrina Reilly, Wen Qu, Barton W Rohrbach |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Methyl Ethers Minimum alveolar concentration Cross-Over Studies Dose-Response Relationship Drug General Veterinary business.industry Motor Activity Loading dose Constant rate infusion Sevoflurane Fentanyl Motor movement Dogs Anesthesia Anesthetics Inhalation Animals Medicine End tidal sevoflurane concentration business Intact male Adjuvants Anesthesia medicine.drug |
| Zdroj: | Veterinary Anaesthesia and Analgesia. 40:290-296 |
| ISSN: | 1467-2987 |
| DOI: | 10.1111/vaa.12013 |
| Popis: | Objective The objectives of this study were to determine the effects of fentanyl on the end-tidal concentration of sevoflurane needed to prevent motor movement (MAC NM ) in response to noxious stimulation, and to evaluate if acute tolerance develops. Study design Randomized cross-over experimental study. Animals Six healthy, adult (2–3 years old), intact male, mixed-breed dogs weighing 16.2 ± 1.1 kg. Methods Six dogs were randomly assigned to receive one of three separate treatments over a 3 week period. After baseline sevoflurane MAC NM (MAC NM-B ) determination, fentanyl treatments (T) were administered as a loading dose (Ld) and constant rate infusion (CRI) as follows: T1-Ld of 7.5 μg kg −1 and CRI at 3 μg kg −1 hour −1 ; T2-Ld of 15 μg kg −1 and CRI at 6.0 μg kg −1 hour −1 ; T3-Ld of 30 μg kg −1 and CRI at 12 μg kg −1 hour −1 . The MAC NM was defined as the minimum end-tidal sevoflurane concentration preventing motor movement. The first post-treatment MAC NM (MAC NM-I ) determination was initiated 90 minutes after the start of the CRI, and a second MAC NM (MAC NM - II ) determination was initiated 3 hours after MAC NM-I was established. Results The overall least square mean MAC NM-B for all groups was 2.66%. All treatments decreased ( p NM , and the decrease from baseline was 22%, 35% and 41% for T1, T2 and T3, respectively. Percentage change in T1 differed ( p NM-I was not significantly different from MAC NM-II within treatments. Conclusions and clinical relevance Fentanyl doses in the range of 3–12 μg kg −1 hour −1 significantly decreased the sevoflurane MAC NM . Clinically significant tolerance to fentanyl did not occur under the study conditions. |
| Databáze: | OpenAIRE |
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