Impact of side-hole geometry on the performance of hemodialysis catheter tips: A computational fluid dynamics assessment

Autor: Shuang Qian, Diana C. de Oliveira, Duncan E.T. Shepherd, Daniel M. Espino, Naomi C. Green, David G. Owen
Rok vydání: 2020
Předmět:
Physiology
030232 urology & nephrology
Geometry
02 engineering and technology
Inflow
Biochemistry
0302 clinical medicine
Animal Cells
Blood Flow
Medicine and Health Sciences
Shear Stresses
Flow Rate
Multidisciplinary
Physics
Models
Cardiovascular
Classical Mechanics
Equipment Design
Body Fluids
Volumetric flow rate
Shear (sheet metal)
Catheter
Blood
Nephrology
Physical Sciences
Engineering and Technology
Mechanical Stress
Medicine
Anatomy
Cellular Types
Blood Flow Velocity
Research Article
Biotechnology
Blood Platelets
Platelets
Catheters
Materials science
Science
0206 medical engineering
Hemodialysis Catheter
Bioengineering
Fluid Mechanics
Residence time (fluid dynamics)
Continuum Mechanics
03 medical and health sciences
Platelet Adhesiveness
Renal Dialysis
Medical Dialysis
Shear stress
Humans
Computer Simulation
Fibrin
Blood Cells
Hemodynamics
Computational Biology
Biology and Life Sciences
Proteins
Fluid Dynamics
Cell Biology
020601 biomedical engineering
Shear rate
Hydrodynamics
Medical Devices and Equipment
Zdroj: PLoS ONE, Vol 15, Iss 8, p e0236946 (2020)
PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0236946
Popis: Hemodialysis catheters are used to support blood filtration, yet there are multiple fundamentally different approaches to catheter tip design with no clear optimal solution. Side-holes have been shown to increase flow rates and decrease recirculation but have been associated with clotting/increased infection rates. This study investigates the impact of changing the shape, size and number of side-holes on a simple symmetric tip catheter by evaluating the velocity, shear stress and shear rate of inflowing blood. A platelet model is used to examine the residence time and shear history of inflowing platelets. The results show that side-holes improve the theoretical performance of the catheters, reducing the maximum velocity and shear stress occurring at the tip compared to non-side-hole catheters. Increasing the side-hole area improved performance up to a point, past which not all inflow through the hole was captured, and instead a small fraction slowly ‘washed-out’ through the remainder of the tip resulting in greater residence times and increasing the likelihood of platelet adhesion. An oval shaped hole presents a lower chance of external fibrin formation compared to a circular hole, although this would also be influenced by the catheter material surface topology which is dependent on the manufacturing process. Overall, whilst side-holes may be associated with increased clotting and infection, this can be reduced when side-hole geometry is correctly implemented though; a sufficient area for body diameter (minimising residence time) and utilising angle-cut, oval shaped holes (reducing shear stress and chances of fibrin formation partially occluding holes).
Databáze: OpenAIRE
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