Previous viral symptoms and individual mothers influenced the leveled duration of human milk antibodies cross-reactive to S1 and S2 subunits from SARS-CoV-2, HCoV-229E, and HCoV-OC43
| Autor: | Veronique Demers-Mathieu, Ciera DaPra, Elena Medo, Gabrielle B. Mathijssen |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
2019-20 coronavirus outbreak Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses Antibody level Enzyme-Linked Immunosorbent Assay Cross Reactions Antibodies Viral Article Coronavirus OC43 Human 03 medical and health sciences Young Adult fluids and secretions 0302 clinical medicine Coronavirus 229E Human 030225 pediatrics Milk antibodies Medicine Humans 030212 general & internal medicine Young adult Innate immunity biology Milk Human business.industry SARS-CoV-2 food and beverages Obstetrics and Gynecology virus diseases COVID-19 Translational research Antibodies Neutralizing Immunoglobulin Isotypes Pediatrics Perinatology and Child Health Immunology Spike Glycoprotein Coronavirus biology.protein Female Antibody business Infection |
| Zdroj: | Journal of Perinatology |
| ISSN: | 1476-5543 0743-8346 |
| Popis: | Objective The influence of previous viral symptoms on the level and duration of human milk antibodies reactive to SARS-CoV-2, and common human coronaviruses (HCoVs) was investigated. Study design Antibodies reactive to S1 and S2 subunits from SARS-CoV-2, HCoV-OC43, and HCoV-229E were measured via ELISA in human milk samples collected from March to June 2020 in mothers with and without viral symptoms. Results The presence of viral symptoms influenced the levels of SARS-CoV-2 S2-reactive SIgA/IgA and tended to influence SARS-CoV-2 S1 SIgA/IgA and S2-reactive SIgM/IgM in human milk but did not relate to IgG. HCoV-229E S1 + S2-reactive SIgA/IgA and SIgM/IgM, as well as HCoV-OC43 S1 + S2-reactive IgG were related to the symptoms. The duration of antibody levels in human milk in mothers with viral symptoms varied between 3 and 4 months post maternal report of viral symptoms. Conclusion Previous viral symptoms and individual mothers may change the antibody cross-reactive levels to SARS-CoV-2 and HCoVs in human milk. |
| Databáze: | OpenAIRE |
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