Regularized Spatial Filtering Method (R-SFM) for detection of Attention Deficit Hyperactivity Disorder (ADHD) from resting-state functional Magnetic Resonance Imaging (rs-fMRI)
| Autor: | Vigneshwaran Subbaraju, Narasimhan Sundararajan, Abhay M S Aradhya, Suresh Sundaram |
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| Přispěvatelé: | School of Electrical and Electronic Engineering, 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Computer science
Feature extraction 02 engineering and technology Brain mapping 03 medical and health sciences 0302 clinical medicine Discriminative model 0202 electrical engineering electronic engineering information engineering medicine Humans Attention deficit hyperactivity disorder Attention Brain Mapping Blood-oxygen-level dependent medicine.diagnostic_test business.industry Brain Pattern recognition Covariance Regularized Spatial Filtering Method (R-SFM) medicine.disease Magnetic Resonance Imaging Attention Deficit Hyperactivity Disorder (ADHD) Attention Deficit Disorder with Hyperactivity Electrical and electronic engineering [Engineering] 020201 artificial intelligence & image processing Artificial intelligence Functional magnetic resonance imaging business 030217 neurology & neurosurgery |
| Zdroj: | EMBC |
| DOI: | 10.1109/EMBC.2018.8513522 |
| Popis: | Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental problem in children. Resting state functional magnetic resonance imaging (rs-fMRI) provides an important tool in understanding the aberrant functional mechanisms in ADHD patients and assist in clinical diagnosis. Recently, spatio-temporal decomposition via spatial filtering (Fukunaga-Koontz transform, ICA) have gained attention in the analysis of fMRI time-series data. Their ability to decompose the blood oxygen level dependent (BOLD) rs-fMRI time series data into discriminative spatial and temporal components have resulted in better classification accuracy and the ability to isolate the important brain circuits responsible for the observed differences in brain activity. However, they are prone to errors in the estimation of covariance matrices due to the significant presence of atypical samples in the ADHD dataset. In this paper, we present a regularization framework to obtain a robust estimation of the covariance matrices such that the effect of atypical samples is reduced. The resulting approach called as regularized spatial filtering method (R-SFM) further uses Mahalanobis whitening to lower the effect of two-way correlations while preserving the spatial arrangement of the data in the feature extraction process. R-SFM was evaluated on the benchmark ADHD200 dataset and not only obtained a 6% improvement in classification accuracy, but also a 66.66% decrease in standard deviation over the previously developed SFM approach. Also R-SFM produces higher specificity which results in lower misclassification of ADHD, thereby reducing the risk of misdiagnosis. These results clearly show that RSFM provides an accurate and reliable tool for detection of ADHD from BOLD rs-fMRI time series data. Accepted version |
| Databáze: | OpenAIRE |
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