Specific activation of operculum 3 (OP3) brain region during provoked tinnitus-related phantom auditory perceptions in humans
| Autor: | Yoann Pons, Roland Jacob, Agnès Job, Chantal Delon-Martin, Jérome Gauthier, M Kossowski, Marc Raynal, Bertrand Lombard |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Auditory Pathways Histology genetic structures media_common.quotation_subject Illusion Sound perception Audiology Somatosensory system behavioral disciplines and activities Tinnitus 03 medical and health sciences 0302 clinical medicine Perception otorhinolaryngologic diseases medicine Humans 030223 otorhinolaryngology Operculum (brain) media_common Auditory Cortex Neural correlates of consciousness Proprioception General Neuroscience Brain Middle Aged Magnetic Resonance Imaging Temporal Lobe medicine.anatomical_structure Acoustic Stimulation Auditory Perception Female sense organs Anatomy medicine.symptom Psychology psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | Brain Structure and Function. 221:913-922 |
| ISSN: | 1863-2661 1863-2653 |
| Popis: | The phantom sound perception mechanism by which a sound perception occurs without any external sound source is still enigmatic. According to our previous fMRI study, a small region in the parietal operculum 3 was hyperactivated as a function of tinnitus periodicity in subjects with acoustic trauma tinnitus sequelae. This region was localized in the vicinity of neural correlates of middle-ear tympano-ossicular chain movements due to pressure variations. Disturbed proprioceptors are known to trigger illusory perceptions; therefore, we hypothesized that a disturbance of middle-ear proprioceptors may originate phantom sound perceptions. We designed an fMRI study that aimed to stimulate middle-ear proprioceptors by repetitive vibrations using various rates of click trains. In this study, we report that exposure to specific rates of stimuli for a few minutes at comfortable intensity level in healthy subjects distinctly triggered transient tinnitus-like aftereffects. The fMRI neural correlates of the aftereffects were unequivocally localized in the same parietal region as in acoustic trauma tinnitus sufferers. Our results strongly suggest that a middle-ear kinesthetic/proprioceptive illusion exists at the origin of acoustic trauma tinnitus via a somatosensory pathway encompassing the trigeminal system. |
| Databáze: | OpenAIRE |
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